Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice

Abstract

In addition, water extracted from P. notoginseng has been confirmed to inhibit human lung carcinoma cells, with the inhibition rate reaching 89%. 13 Several studies have shown that steaming P. notoginseng roots increased the antitumor activity. [14][15][16][17] In Vietnam, P. notoginseng grows wildly and is also grown in the high mountains in the north. However, research to evaluate the effect on tumors of raw or steamed P. notoginseng roots is lacking. The study evaluated and compared the antitumor effects of saponin-rich extracts from steamed and raw P. notoginseng roots collected in Vietnam on Swiss mice bearing solid sarcoma TG 180 tumors. Materials and methods Plant materialThe roots used were from 4-year-old tuberous P. notoginseng (Burk.) F.H. grown in Simacai village, Lao Cai province, in the north of Vietnam. The roots were collected in July 2015 and indentified by Dr.