Panax ginseng methabolit (GIM-1) prevents oxidative stress and apoptosis in human Sertoli cells exposed to Monobutyl-phthalate (MBP)

Freitas, André Teves Aquino Gonçalves de; Pinho, Cristiane Figueiredo; Aquino, Ariana Musa de; Fernandes, Ana Angélica Henrique; Domeniconi, Raquel Fantin; Justulin, Luis Antônio; Scarano, Wellerson Rodrigo

doi:10.1016/j.reprotox.2019.02.008

Cited by 11 publications

(8 citation statements)

References 53 publications

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“…However, Pnx-feeding significantly increased plasma TAC and reduced TOS levels in the CPinduced testicular damage. De Freitas et al showed that Pnx metabolite (GIM-1) prevented oxidative stress and apoptosis in human Sertoli cells via increased SOD, CAT, GPx, and caspase-3 levels (De Freitas et al, 2019). In another study, in GC-2 sperm cells, Pnx prevented hydrogen peroxide-induced oxidative stress via increased GPx expression (Kopalli et al, 2016).…”

Section: Discussionmentioning

confidence: 98%

“…However, it also damages many tissues such as the kidney, brain, liver, and testis due to its intense cytotoxic activity (Dasari et al, 2014;Hanigan et al, 2003). Many studies examining its effects on the testis have been repeatedly shown that CP causes mitochondriamediated oxidative stress, apoptosis, inflammation, and gonadotoxicity (Aly et al, 2020;Ceylan et al, 2020;De Freitas et al, 2019). Recently, research investigating Ginger juice's effects on CP-induced testicular damage showed that rats' body weights did not change at the end of the fifth day after CP administration.…”

Section: Discussionmentioning

confidence: 99%

“…In another study, Korean Ginseng increased C-21 steroid metabolism in the testis' interstitial Leydig cells (Kim et al, 2011). However, many studies suggested that Pnx decreases oxidative stress and increases antioxidant capacity in various tissues (De Freitas et al, 2019;Kopalli et al, 2016;Kumar et al, 2003).…”

Section: Introductionmentioning

confidence: 94%

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Panax ginseng’in sıçanlarda sisplatin ile oluşturulan testis hasarı üzerine etkileri

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Güzel

et al. 2021

Anatolian Journal of Botany

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Infertility has become an increasingly important health problem due to genetic, familial, hormonal, and congenital abnormalities, environmental and chemical reasons. This study aimed to investigate the effects of Panax ginseng (Pnx) root extract on cisplatin (CP) induced testicular damage of rats. Four animal groups were applied with different protocols as control, Pnx (200 mg / kg), CP (7 mg / kg), and CP + Pnx (200 mg / kg). At the end of the experiment, the body and testicular weights of the rats were measured. While free/total testosterone, total antioxidant capacity (TAC), and total oxidative species (TOS) levels were analyzed in blood samples, apoptotic cells were marked by TUNEL staining in testicular samples of rats. According to the results, free/total testosterone and TAC levels were decreased while TOS levels increased in injured rats' plasma. On the other hand, seminiferous tubule diameters widened, and the number of apoptotic cells increased in rats' testis. These variables were significantly improved with the consumption of Pnx. As a result, Pnx has a significant protective effect on testicular tissue; however, further studies are needed to elucidate its action mechanism.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Panax ginseng’in sıçanlarda sisplatin ile oluşturulan testis hasarı üzerine etkileri

Aslan

Kumalar

Güzel

et al. 2021

Anatolian Journal of Botany

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“…Antioxidants such as GSH, GPx, CAT, SOD play important protective roles against oxidative stress. While GSH controls cellular redox changes related to ROS production, CAT and GPx take part in hydrogen peroxide catabolism (Ballatori et al, 2009;De Freitas et al, 2019;Uyar et al, 2018). In this study, it was determined that GSH level, CAT…”

Section: Discussionmentioning

confidence: 99%

The protective effect of esculetin against aluminium chloride‐induced reproductive toxicity in rats

et al. 2020

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The metals are ubiquitous in nature and they have a wide range of uses in industry. They remain in nature for a long time and it is very difficult for mankind to protect himself from metal exposure (Pizent et al., 2012). Aluminium is one of the most common elements in the earth's crust and takes only the value of +3 (Mayyas et al., 2005). It becomes inevitable for people to be exposed to Aluminium because of their presence in dust particles in the air, food additives, phosphate binders, antacids, buffered analgesics, antiperspirants, cooking containers, canned boxes, baby formulations, cosmetics, mining, drinking water and some herbal products

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“…In China, Panax ginseng in traditional Chinese medicine has been employed to be a tonic drug for more than 2000 years. Some studies indicated that monobutyl phthalate (MBP) reduced the expression of adhesion molecules and disrupted the structure of the blood‐testis barrier (BTB) in human Sertoli cells, while Panax ginseng metabolite played a protective role in human Sertoli cells exposure to MBP 24‐26 . Ginsenoside Rg1, a chiefly component, has been suggested to treat some diseases through its antiaging, antioxidant, antiapoptotic, and memory improvement properties 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di‐N‐butyl‐phthalate

Qu²,

Qian

et al. 2020

Environmental Toxicology

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With the aggravation of environmental pollution, the incidence of infertility is increasing. Ginsenoside Rg1 is a monomer component extracted from Panax ginseng. It has been found that Ginsenoside Rg1 is able to prevent premature ovarian failure and delay testicular senescence. Therefore, we speculate Ginsenoside Rg1 may have great potential to prevent and treat infertility. The aim of this work is to explore whether Ginsenoside Rg1 plays a protective role in the dinbutyl phthalate (DBP)‐induced reproductive function injury mice, and to elucidate the potential mechanism. C57BL/6J male mice were administered by DBP with or without Ginsenoside Rg1 treatment and serum, testis and epididymis were collected for further analysis. Sperm analysis, hematoxylin and eosin staining, and serum hormone detection indicated that Ginsenoside Rg1 treatment improved the sperm density and sperm motility, reduced the testicular tissue damage, increased the serum testosterone and luteinizing hormone levels, and decreased the serum follicle‐stimulating hormone level in DBP‐induced mice. Furthermore, Ginsenoside Rg1 treatment upregulated expression levels of spermatogenesis‐related protein, Cx43, E‐cadherin, p‐PI3K, p‐Akt, and mTOR in the mice treated by DBP, observed by using a immunohistochemistry assay, a real‐time quantitative PCR assay, and a western blot analysis. The present study reveals that Ginsenoside Rg1 may exert anti‐DBP‐induced reproductive function injury in C57BL/6J mice. In addition, the protect role of Ginsenoside Rg1 in spermatogenesis may be associated with the regulation of reproductive hormones, upregulation of spermatogenic associated proteins expression, restoration of the gap junctions, and the activation of PI3K/Akt/mTOR signaling pathways.

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Panax ginseng methabolit (GIM-1) prevents oxidative stress and apoptosis in human Sertoli cells exposed to Monobutyl-phthalate (MBP)

Cited by 11 publications

References 53 publications

Panax ginseng’in sıçanlarda sisplatin ile oluşturulan testis hasarı üzerine etkileri

Panax ginseng’in sıçanlarda sisplatin ile oluşturulan testis hasarı üzerine etkileri

The protective effect of esculetin against aluminium chloride‐induced reproductive toxicity in rats

Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di‐N‐butyl‐phthalate

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