Pan-omics focused to Crick's central dogma

Jaiswal, Arun Kumar; Tiwari, Sandeep; Tavares, Guilherme Campos; Silva, Wanderson Marques da; Oliveira, Letícia de Castro; Ibraim, Izabela Coimbra; Guimarães, Luís Carlos; Gomide, Anne Cybelle Pinto; Jamal, Syed Babar; Pantoja, Yan; Tiwary, Basant K.; Burkovski, Andreas; Munir, Faiza; Thi, Hai Ha Pham; Ullah, Nimat; Ali, Amjad; Giovanetti, Marta; Alcântara, Luiz Carlos Júnior; Kaur, Jaspreet; Dhawan, Dipali; Imchen, Madangchanok; Vennapu, Ravali Krishna; Kumavath, Ranjith; Corredor, Mauricio; Figueiredo, Henrique César Pereira; Barh, Debmalya; Azevedo, Vasco; Soares, Siomar de Castro

doi:10.1016/b978-0-12-817076-2.00001-9

Cited by 4 publications

(2 citation statements)

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“…The Pangenome of Pseudomonas aeruginosa shared and syntheny, plasticity, evolution, and others. The development of pangenomics has promoted advances in many fields, like bioinformatics and computational biology, comparative genomics, molecular medicine, molecular epidemiology, agronomy and foods, and many more [18]. In the beginning, one advantage of pangenomics was that experimental data have shown for some species that new genes are being discovered even after sequencing several strain genomes [19].…”

Section: What Is a Pangenome?mentioning

confidence: 99%

The Pangenome of Pseudomonas aeruginosa

Corredor¹,

Patiño-Salazar²,

Castaño³

et al. 2024

Pseudomonas Aeruginosa - New Perspectives and Applications

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This review summarizes the most important reports about Pseudomonas aeruginosa pangenome. Pan-genomics has tackled some fundamental concerns in pathogenic bacteria. PATRIC and other databases, store more than 9000 P. aeruginosa genomes. This data mining is an opportunity to develop discoveries related to antibiotic resistance, virulence, pathogenicity, fitness, and evolution, among others. Observing the different pangenomes of P. aeruginosa, it is concluded that this species has an open pangenome, and its accessory genome is larger than the central genome. HGT is one important source for P. aeruginosa genome. In recent years various authors developed P. aeruginosa pangenomes, from works with five genomes to more than 1300 genomes. This last work analyzed 54,272 genes, and they found a short and tiny core genome (only 665 genes). Other research with lesser strains or genomes identified a core genome bigger, almost 20% of the pangenome. Nevertheless, the total work proves that the accessory plus unique genome is larger than the core genome in P. aeruginosa.

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Section: What Is a Pangenome?mentioning

confidence: 99%

The Pangenome of Pseudomonas aeruginosa

Corredor¹,

Patiño-Salazar²,

Castaño³

et al. 2024

Pseudomonas Aeruginosa - New Perspectives and Applications

Self Cite

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“…It is also possible to identify which genes are not part of the core collection and which are essential—that is, those that are found in all or most of the lineages ( Figure 1 ). The core genes are conserved, while the accessory genes, present in only some individuals or lineages, are more variable [ 3 , 5 , 34 , 35 ]. Moreover, genetic segments that are part of the accessory genome can be further subdivided in the “dispensable” or “shell” genome (i.e., structures that are shared by at least two subjects) and the “unique” or “cloud” genome (i.e., the collection of genomic elements that are specific to a single individual).…”

Section: Characteristics Of the Pangenomementioning

confidence: 99%

Human Pangenomics: Promises and Challenges of a Distributed Genomic Reference

Abondio

Cilli

Luiselli

2023

Life

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A pangenome is a collection of the common and unique genomes that are present in a given species. It combines the genetic information of all the genomes sampled, resulting in a large and diverse range of genetic material. Pangenomic analysis offers several advantages compared to traditional genomic research. For example, a pangenome is not bound by the physical constraints of a single genome, so it can capture more genetic variability. Thanks to the introduction of the concept of pangenome, it is possible to use exceedingly detailed sequence data to study the evolutionary history of two different species, or how populations within a species differ genetically. In the wake of the Human Pangenome Project, this review aims at discussing the advantages of the pangenome around human genetic variation, which are then framed around how pangenomic data can inform population genetics, phylogenetics, and public health policy by providing insights into the genetic basis of diseases or determining personalized treatments, targeting the specific genetic profile of an individual. Moreover, technical limitations, ethical concerns, and legal considerations are discussed.

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