The Pangenome of Pseudomonas aeruginosa

Abstract

This review summarizes the most important reports about Pseudomonas aeruginosa pangenome. Pan-genomics has tackled some fundamental concerns in pathogenic bacteria. PATRIC and other databases, store more than 9000 P. aeruginosa genomes. This data mining is an opportunity to develop discoveries related to antibiotic resistance, virulence, pathogenicity, fitness, and evolution, among others. Observing the different pangenomes of P. aeruginosa, it is concluded that this species has an open pangenome, and its accessory genome is larger than the central genome. HGT is one important source for P. aeruginosa genome. In recent years various authors developed P. aeruginosa pangenomes, from works with five genomes to more than 1300 genomes. This last work analyzed 54,272 genes, and they found a short and tiny core genome (only 665 genes). Other research with lesser strains or genomes identified a core genome bigger, almost 20% of the pangenome. Nevertheless, the total work proves that the accessory plus unique genome is larger than the core genome in P. aeruginosa.

Alleleomes characterize the survivors of 3.5 billion years of bacterial evolution

“…The large number of available sequenced bacterial genomes [2][3][4][5] has enabled big data analysis of the sequence variants of genes, and led to the de nition of the alleleome 7 . In contrast, pan-genome analyses are based on presence/absence calls for individual genes in a set of genomes for strains of a species [32][33][34][35][36][37][38] . Thus, the alleleome is a ne-grained version of the pangenome and illuminates new information about sequence variation and selection.…”