Pan-drug-resistant and biofilm-producing strain of <em>Burkholderia pseudomallei</em>: first report of melioidosis from a diabetic patient in Yogyakarta, Indonesia

Abstract

Melioidosis, an infectious disease caused by Burkholderia pseudomallei, has recently gained importance as an emerging infectious disease in Indonesia. Reports of this infection in Indonesia are limited, although cases have been reported in Makassar, South Sulawesi. We report a case of cutaneous melioidosis caused by pan-drug-resistant, moderate biofilm-producer strain of B. pseudomallei in a diabetic patient. To the best of our knowledge, this is the first case of melioidosis caused by multidrug resistant and biofilm-former strain of B. pseudomallei being reported from Yogyakarta Province, Indonesia. The patient was successfully treated with abscess drainage and debridement, including total contact casting and no antibiotic treatment.

Prevalence of Burkholderia cepacia recovered from clinical specimens in the Zainoel Abidin general hospital, Banda Aceh, Indonesia

“…The use of surveillance programs and careful administration of antibiotics can help prevent the spread of B. cepacia infections, even though some medications are still effective against it. This is because other groups of Burkholderia bacteria, such as Burkholderia pseudomallei , which causes meliodosis and has been detected in human and environmental samples, can develop resistance to pan-drug resistance in certain regions ( 26 ), including Indonesia ( 27 ).…”

<p>Pan-drug-resistant and biofilm-producing strain of <em>Burkholderia pseudomallei</em>: first report of melioidosis from a diabetic patient in Yogyakarta, Indonesia [Response to Letter]</p>

“…We thank Dr David Dance et al from the International Melioidosis Society Committee for their interest in our case report. This is a response to their letter, which argued that our paper1 does not support convincing identification of Burkholderia pseudomallei . In our study, we performed culture on Ashdown agar and identification by Gram staining (Gram-negative bacilli), positive oxidase test, and biochemical testing by API 20NE.…”

Characterization of Burkholderia pseudomallei from spontaneous melioidosis in a Bornean orangutan

“…To the best of our knowledge, there is no published report available on a successful treatment of melioidosis in NHPs. Infection caused by B. pseudomallei may be difficult to be treated since resistance to many antibiotics has been perceived for these bacteria [18,[58][59][60]. In human patients, antibiotic treatment for melioidosis is divided into two phases, namely, Phase 1 for the acute infection and Phase 2 for the eradication [61].…”