Palmitoyl ascorbate: Selective augmentation of procollagen mRNA expression compared with L‐ascorbate in human intestinal smooth muscle cells

Rosenblat, Gennady; Willey, Amy; Zhu, Yanan; Jonas, Adi; Diegelmann, Robert F.; Néeman, I.; Graham, Martin F.

doi:10.1002/(sici)1097-4644(19990601)73:3<312::aid-jcb3>3.3.co;2-t

Cited by 4 publications

(5 citation statements)

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“…In other cultured human fibroblast experiments, MAP was found to be equivalent to AA in stimulating collagen synthesis, while SAP required at least a tenfold greater concentration to produce the same effect as AA . AA‐Pal augmented human intestinal smooth muscle cells procollagen synthesis in vitro more effectively than AA but induced similar increases in the amounts of newly synthesized collagen secreted into the medium …”

Section: Neocollagenesismentioning

confidence: 83%

“…58 AA-Pal augmented human intestinal smooth muscle cells procollagen synthesis in vitro more effectively than AA but induced similar increases in the amounts of newly synthesized collagen secreted into the medium. 59 AA also plays a role in collagen synthesis at the level of gene expression. 60,61 It has been shown to up-regulate collagen synthesis and increase the synthesis of the inhibitor of metalloproteinase-I 62 which decreases UV-induced collagen degradation.…”

Section: Neocollagenesismentioning

confidence: 99%

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Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives

Stamford¹

2012

J of Cosmetic Dermatology

112

132

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Topically applied antioxidants exert their benefits by offering protection from damaging free radicals and over-the-counter cosmeceuticals incorporating antioxidants are among the most popular anti-aging products available. One potent antioxidant of particular note, vitamin C, has been extensively utilized because it possesses a variety of other cutaneous benefits including photoprotection from UV A & B, neocollagenesis, inhibition of melanogenesis and improvement of a variety of inflammatory skin disorders. However, the instability of this water-soluble vitamin, together with difficulties associated with its topical delivery, has presented issues for the formulation chemist. This article reviews the scientific data and clinical studies that underpin the stability, percutaneous absorption, and cutaneous effects of vitamin C together with its commonly utilized, commercially available derivatives.

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Section: Neocollagenesismentioning

confidence: 83%

Section: Neocollagenesismentioning

confidence: 99%

Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives

Stamford¹

2012

J of Cosmetic Dermatology

112

132

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“…The largest number of matched hits was for ascorbate and aldarate metabolism, phenylalanine, linoleic, and arginine, and proline metabolism. Notable contributions came from metabolites attributed to ascorbate and proline metabolism, suggesting variation in collagen production and thus differences in cell matrix features. − Although ascorbate is instrumental in collagen production, it is expected that the variance observed with ascorbate metabolism has been somewhat biased by the inclusion of ascorbate-2-phosphate as a component of the OIM culture media. Linoleic acid metabolism, which contributes to the differences noted between sample types, is known to play an important role in bone development − as well as acting as precursor for a class of broad range cell membrane signaling molecules (eicosanoids), inferring significant differences in cellular regulation …”

Section: Resultsmentioning

confidence: 99%

Nacre Topography Produces Higher Crystallinity in Bone than Chemically Induced Osteogenesis

et al. 2017

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It is counterintuitive that invertebrate shells can induce bone formation, yet nacre, or mother of pearl, from marine shells is both osteoinductive and osteointegrative. Nacre is composed of aragonite (calcium carbonate) and induces production of vertebrate bone (calcium phosphate). Exploited by the Mayans for dental implants, this remarkable phenomenon has been confirmed in vitro and in vivo, yet the characteristic of nacre that induces bone formation remains unknown. By isolating nacre topography from its inherent chemistry in the production of polycaprolactone (PCL) nacre replica, we show that, for mesenchymal stem cells, nacre topography is osteoinductive. Gene expression of specific bone marker proteins, osteopontin, osteocalcin, osteonectin, and osterix, is increased 10-, 2-, 1.7-, and 1.8-fold, respectively, when compared to planar PCL. Furthermore, we demonstrate that bone tissue that forms in response to the physical topographical features of nacre has a higher crystallinity than bone formed in response to chemical cues with a full width half-maximum for PO Raman shift of 7.6 ± 0.7 for mineral produced in response to nacre replica compared to a much broader 34.6 ± 10.1 in response to standard osteoinductive medium. These differences in mineral product are underpinned by differences in cellular metabolism. This observation can be exploited in the design of bone therapies; a matter that is most pressing in light of a rapidly aging human population.

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“…The 16‐carbon chain of PA affects both physico‐chemical and biophysiological properties of this molecule. Thus, PA has greater potency to affect the redox state in mammalian cells [28], alter DNA synthesis in tumor cells and their proliferation [29], suppress the posttranscriptional induction of ornithine decarboxylase [30], affect collagen synthesis in cultured cells [31,32] and inhibit NADPH oxidase activity [33].…”

Section: Discussionmentioning

confidence: 99%

Diverse effects of ascorbic acid and palmitoyl ascorbate onHelicobacter pylorisurvival and growth

Tabak

Armon

Rosenblat

et al. 2003

FEMS Microbiology Letters

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Among many antioxidants used in the food, pharmaceutical and cosmetic industries, ascorbic acid (AA) is one of the most important. AA has been suggested to decrease the risk of gastric disease (gastritis, duodenal ulcer, and carcinoma) by direct action on Helicobacter pylori. However, there are limited studies on the possible role of AA and its derivatives such as palmitoyl ascorbate (PA) on the growth and survival of H. pylori. In the present study it was demonstrated in vitro that AA in the concentration range 10-20 mg x ml(-1) (50-100 mM) inhibited H. pylori growth in liquid medium under microaerophilic conditions. In contrast, under aerobic conditions AA in the concentration range 2-20 mg x ml(-1) (10-100 mM) significantly increased the survival of H. pylori presumably eliminating the toxic effect of reactive oxygen species on bacterial cells. The hydrophobic derivative of AA, PA (a food antioxidant), demonstrated a strong antibacterial effect, under both aerobic and microaerophilic conditions in the concentration range 0.04-0.4 mg x ml(-1) (0.1-1.0 mM). This effect was also tested on other bacterial strains: Escherichia coli, Proteus vulgaris, Proteus mirabilis, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Clostridium sporogenes and Campylobacter jejuni. Among these bacterial strains, PA showed a similar inhibitory effect on B. cereus and B. subtilis as observed with H. pylori. The results suggest that PA may be considered an important AA derivative in eradication of H. pylori in vitro and in vivo and to decrease the risk for gastric diseases.

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Palmitoyl ascorbate: Selective augmentation of procollagen mRNA expression compared with L‐ascorbate in human intestinal smooth muscle cells

Cited by 4 publications

References 0 publications

Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives

Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives

Nacre Topography Produces Higher Crystallinity in Bone than Chemically Induced Osteogenesis

Diverse effects of ascorbic acid and palmitoyl ascorbate onHelicobacter pylorisurvival and growth

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