Palmatine regulates bile acid cycle metabolism and maintains intestinal flora balance to maintain stable intestinal barrier

Ning, Yayuan; Xu, Fei; Xin, Rui; Yao, Fang

doi:10.1016/j.lfs.2020.118405

Cited by 14 publications

(6 citation statements)

References 35 publications

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“…Intestinal BA could inhibit the proliferation and translocation of the gut microbiota and positively affect the stability of intestinal barrier function . Studies have shown that the long-time HFD intake significantly impaired gut barrier function, which might increase the susceptibility of the body to harmful substances in the gut. , Intestinal BA acts as a chemical barrier for intestinal mucosa and removes endotoxin lipopolysaccharide (LPS) .…”

Section: Discussionmentioning

confidence: 99%

Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

Duan

Guan

Huang

et al. 2021

J. Agric. Food Chem.

125

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A high-fat diet (HFD) causes hyperlipidemia, which worsens disturbances in bile acid (BA) metabolism and gut microbiota. This study aimed to investigate the regulation of flavonoids from whole-grain oat (FO) on BA metabolism and gut microbiota in HFD-induced hyperlipidemic mice. The experiment results showed that FO improved serum lipid profiles and decreased body weight and lipid deposition in HFD-fed mice. Through real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot assays, by up-regulating the expression of PPARα, CPT-1, CYP7A1, FXR, TGR5, NTCP, and BSTP, and downregulating those of SREBP-1c, FAS, and ASBT, FO suppressed lipogenesis, promoted lipolysis and BA synthesis, and efflux to faeces via the FXR pathway. 16s rRNA sequencing revealed that FO significantly increased Akkermansia and significantly decreased Lachnoclostridium, Blautia, Colidextribacter, and Desulfovibrio. Spearman's correlation analysis showed that these bacteria were strongly correlated with hyperlipidemia-related parameters. Therefore, our results indicated that FO possessed an antihyperlipidemic effect via regulating the gut−liver axis, i.e., BA metabolism and gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

Duan

Guan

Huang

et al. 2021

J. Agric. Food Chem.

125

View full text Add to dashboard Cite

show abstract

“…Food & Function ence the proliferation and translocation of the gut microbiota and positively affect the stability of intestinal barrier function. 48 DCA has a strong inhibitory effect on the growth of bacteria, and its effect is 10 times that of CA. 49 High-fat feeding during the rest period led to a significant increase in DCA levels at ZT0, while APE treatment reduced DCA levels.…”

Section: Papermentioning

confidence: 98%

Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding C57BL/6 male mice

et al. 2022

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“…It showed that 258 reduced HFD-induced lipid accumulation in the liver. So, it indicated the curative effect of 258 for hyperlipidemia ( Ning et al, 2020 ).…”

Section: Natural Products Targeting Farnesoid X Receptormentioning

confidence: 98%

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor

She

Pang

et al. 2022

Front. Pharmacol.

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Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals. Among NRs, the liver X receptors (LXRs) and farnesoid X receptor (FXR) have been of significance as targets for the treatment of metabolic syndrome-related diseases. In recent years, natural products targeting LXRs and FXR have received remarkable interests as a valuable source of novel ligands encompassing diverse chemical structures and bioactive properties. This review aims to survey natural products, originating from terrestrial plants and microorganisms, marine organisms, and marine-derived microorganisms, which could influence LXRs and FXR. In the recent two decades (2000–2020), 261 natural products were discovered from natural resources such as LXRs/FXR modulators, 109 agonists and 38 antagonists targeting LXRs, and 72 agonists and 55 antagonists targeting FXR. The docking evaluation of desired natural products targeted LXRs/FXR is finally discussed. This comprehensive overview will provide a reference for future study of novel LXRs and FXR agonists and antagonists to target human diseases, and attract an increasing number of professional scholars majoring in pharmacy and biology with more in-depth discussion.

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Palmatine regulates bile acid cycle metabolism and maintains intestinal flora balance to maintain stable intestinal barrier

Cited by 14 publications

References 35 publications

Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding C57BL/6 male mice

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor

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