Palmar Crease Variants and Their Clinical Significance: A Study of Newborns at Risk

Prevalences of Simian, Sydney and Suwon Creases and their Association with Each Other, Body Sides, Handedness, Sex and Anomalies/Diseases/Syndromes in a Population of Central India

“…Palm creases are helpful in revealing the anthropologic characteristics of the populations of different ethnic origins. For example, the frequencies of normal, Simian, and Sydney creases are different between Caucasians and Negroes (Dar et al, 1977).…”

The Enigma of Simian Crease: Case series with literature review

“…13 It is frequently seen among Asians and Native Americans than among other populations, and in some families there is a tendency to inherit the condition unilaterally. [2][3][4]10,13 In our study, the doctor has SC on the both palms and is normal according to the various studies. 13 Palm creases have additional features that might indicate the possibility of chromosomal aberrations.…”

“…11,12 Single palmar creases are less common than two palmar creases, however 10% of the population have one SC on one hand and 5% have one SC on both hands. 2,3,10 Males are twice more common than females to have this characteristic, and it tends to run in families. 13 It is frequently seen among Asians and Native Americans than among other populations, and in some families there is a tendency to inherit the condition unilaterally.…”

“…Hence, SC should not be used as an independent test to diagnose DS. 6 SC are also useful for diagnosing intrauterine toxin exposure, 3,17 fetal alcoholic syndrome, mental retardation, neoplasia, and other diseases. 14,19 A unilateral SC was also reported in the case of chromosome 9 mutation causing nevoid basal cell carcinoma syndrome and Robinow syndrome.…”

“…2 As palm creases and SC, in per se, are helpful in discovering anthropologic characteristics and diagnosing several diseases, including chromosomal aberrations, they have been analyzed qualitatively 2 and quantitatively. 3 Larger studies were done in children with cytogenetically confirmed patients of Down's syndrome (DS) and SC is common in DS. 4 As DS is commonly seen, in any child with a SC the first premonition is to look for any signs of trisomy 21.…”