If one attempts to compare the most familiar contemporary plans of extrapyramidal connections, such as those of the Vogts, Jakob, Kappers, Huber and Crosby, Papez, Hanson, Bucy and others, it is immediately obvious that many of these arrangements are mutually exclusive and a laborious task is imposed upon the investigator who personally attempts to determine the validity for any particular pathway. This is merely a difficult academic problem for the professional anatomist but it is a pressing and practical one for the clinician who is desirous of visualizing the pathologic mechanisms of extrapyramidal syndromes. Although the literature is confusing and contradictory it is doubtful whether it is wise to discard it, as the Ransons ('41) proposed. It is, nevertheless, presently impossible, in the face of restrictions upon paper, to review preceding work and it will be assumed that the variations in the literature are sufficiently familiar so that a need for a systematic investigation of the connections of the corpus striatum will have been felt. With this end in view we have gone through the experimental material which we have collected in the last 3 years and selected the most significant cases for present study.Of the animals operated up to 3-25'43 (a tabulation of the total material available is given in Met.tler, '44) sixteen cases (15, 30, 31, 33, 36, 37, 39, 62, 63, 71, 90, 100, 101, 104