Palliative radiotherapy and chemotherapy instead of surgery in symptomatic rectal cancer with synchronous unresectable metastases: a phase II study

Abstract

The trial is registered with ClinicalTrials.gov: number NCT01157806.

Palliative pelvic radiotherapy for symptomatic rectal cancer – a prospective multicenter study

“…As opposed to longer courses of palliative radiotherapy that steal time away from systemic treatment, simplified radiotherapy has the advantage that it can be more easily integrated in treatment algorithms that include systemic therapy. 5 Gy  5 fractions to the rectal tumor followed by systemic chemotherapy is a good example of such an integrated approach and has been shown to generate a sustained palliative effect of previously untreated RC in patients with metastatic disease [25].…”

Palliative radiotherapy and chemotherapy instead of surgery in symptomatic rectal cancer with synchronous unresectable metastases: long-term results of a phase II study

“…We have therefore conducted a phase II trial to evaluate whether the palliative effect of radiotherapy and chemotherapy is sufficient to spare patients from palliative surgery. With short follow-up we previously reported favorable results [1]. It is, however, unclear whether such outcomes are long-lasting.…”

“…Material and methods have been previously detailed elsewhere [1]. The primary end-point was the rate of surgery performed for palliation of local symptoms that were uncontrolled by upfront short-course radiotherapy and chemotherapy.…”

May depressed and anxious patients with carcinoid syndrome benefit from treatment with selective serotonin reuptake inhibitors (SSRIs)?: findings from a case report

“…To the Editor, Carcinoid tumors are relatively rare. Incidence rates for men and women are 2.0 and 2.4 per 100 000, respectively [1]. Carcinoid syndrome is usually seen in patients with metastatic disease and is characterized by flushing, diarrhea, bronchial constriction and heart valve dysfunction.…”