Palliative effects of Moringa olifera ethanolic extract on hemato-immunologic impacts of melamine in rats

Abd‐Elhakim, Yasmina M.; Bohi, Khlood M. El; Hassan, Sahar Khalifa; Sayed, Shorouk El; Abdel-Motal, Sabry M.

doi:10.1016/j.fct.2018.02.020

Cited by 33 publications

(8 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, a global trend has focused on incorporating natural antioxidants as strategies to mitigate the side effects of drug use [3,4]. Herbal medicines can modulate many functions including free radical release, histamine release, phagocytosis, and cytokine and immunoglobulin secretion with the regulation of cell receptors and lymphocyte expression [5][6][7]. One of the widely used medicinal plants is Saussurea lappa (S. lappa), family Asteraceae, which is commonly known as Costus.…”

Section: Introductionmentioning

confidence: 99%

Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: In this era, worldwide interest has been directed towards using natural antioxidants to guard against drug side effects. Saussurea lappa is a famous medicinal plant with many biologically active compounds. Triamcinolone acetonide (TA) is an extensively used glucocorticoid. Hence, this study explored, for the first time, the possible beneficial effects of S. lappa ethanolic extract on TA-induced oxidative damage in the lung and spleen of rats. Methods: Five experimental groups were used: control group, S. lappa-treated group (600 mg/kg/day, orally), TA-treated group (40 mg/kg/twice/week I/P), S. lappa + TA co-treated group, and S. lappa/TA prophylactic group. Results: TA exposure significantly induced leukocytosis and neutrophilia. In addition, TA significantly reduced the levels of C-reactive protein, interleukin-12, tumor necrosis factor α, and immunoglobulins. Lung Caspase-3 overexpression and splenic CD8+ downregulation were also noted in the TA group. TA treatment significantly increased malondialdehyde concentration but reduced superoxide dismutase and glutathione peroxidase activities. S. lappa counteracted the TA oxidative and apoptotic effects. The best results were recorded in the prophylactic group. Conclusions: S. lappa has a remarkable protective effect via its anti-inflammatory, anti-apoptotic, and antioxidant capacity. Thus, it could be a candidate as a natural antioxidant to face glucocorticoid’s harmful side effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…[12] In current scenario, more attention has to be given to use of herbal medicinal plants for therapeutic effects or to reduce adverse drug impacts. [13][14][15] Caryota urens is a palm tree, which belongs to Palmae family. This plant is native to Sri Lanka, India and Nepal.…”

Section: Abstract a R T I C L E I N F Omentioning

confidence: 99%

Evaluation of Cell Viability Effects and Antioxidant Activity of Caryota urens Linn. and Couroupita guianensis aublet Leaves in a Model of Ehrlich Ascites Carcinoma as a Xenograft model

TRIVEDI,

Patel,

Patel

et al. 2023

Int. J. Pharm. Sci. Drug Res.

View full text Add to dashboard Cite

Plants used in traditional medicine have been identified as the primary source of anticancer agents. One of the cancer-related parameters is the cell viability parameter. Current study aimed to evaluate cell viability effects and antioxidant activity of Caryota urens Linn. and Couroupita guianensis aublet leaves using xenograft model by transplantation of ehrlich ascites carcinoma (EAC) cells into mice. Animals were randomly divided into seven groups of six animals each. For 10 days, EAC cells (2 × 106 cells/mouse) were injected i.p. into each mouse in each group except the normal control and vehicle control groups. The treatment drugs were compared with standard 5-fluorouracil. Group I received water as a control, group II received 0.9% normal saline, group III received 0.5% CMC, group IV received EAC cells as a model control group, group V received EAC cells with 5-flourouracil treatment, group VI received EAC cells with C. urens linn extract, and group VII received EAC cells with C. guianensis aublet. After 10 days of treatment, animals were sacrificed, ascitic fluid was collected for evaluation of cell viability effects, blood collected for hematological parameter estimation, and liver tissue was collected for histopathological study and evaluation of antioxidant activity. Study results of C. urens linn and C. guianensis aublet both shows significant positive effects on cell viability and antioxidant activity. In the study visible differences were observed in liver tissue of different groups. Disease control groups showed damaged liver cells, while the treatment group showed less damage than disease control. Both plants produced positive effects on cell viability and antioxidant activity, resulting in a decrease in viable cell count.

show abstract

“…Previous research reports concluded that M. oleifera is an immunomodulatory agent that can stimulate the production of IgG, IgM and IgA (Al-Badawi et al, 2016, El Gendy et al, 2017, Al-Majali et al, 2017and Abd-Elhakim et al, 2018 as well as the aqueous extract of M. oleifera showed a strong immune-modulating effect that could modulate B-cell activation and stimulate the production of IgM, IgA and IgG level after administration (Ojeka et al 2016), and T cells where it will result for induction of IL 10 production (Fard et al 2015;Tan et al 2015) and inhibit production of TNFα, IL-6, IL-8 (Kooltheat et al 2014) andIL-2 (Sashidhara et al 2009).…”

Section: Ii-effect Of Mol and Mosc Supplementation In Rations Of Bark...mentioning

confidence: 99%

Effect of Moringa Olifera Supplementation on Immune Response, Oxidative Stress in Barki Rams

Fathy

Nebar

Abdelaziz

et al. 2022

Menoufia Journal of Animal Poultry and Fish Production

View full text Add to dashboard Cite

Fifteen Barki ram were used to study the effect of MOL or MOSC supplementation in the ration on IR, MAD, TAC, IgG, IgM, WBCs, serum transaminases and renal function. The rams were divided into 3 groups. Rams in G1 were fed a basal diet supplemented with MOL (0.5% of CFM/day), rams in G2 were fed a basal diet supplemented with MOSC (10% of CFM/day) while G3 were fed a basal diet without supplementation. The results indicated that supplementation with MOSC increased antibodies after immunization, TAC and decreased MAD in blood samples of rams fed a ration containing MOSC or MOL compared to those rams fed moringa-free rations in contrast to the activity of MAD. The highest IgG recorded in blood samples of rams fed MOl followed by that measured in rams fed MOSC, the lowest was for rams fed a Moringa-free ration. However, the highest IgM recorded in rams fed MOSC followed by that in rams fed a Moringa-free ration and the lowest for rams fed ration with MOL. MOSC or MOL supplementation slightly increased WBC and neutrophil cells, supplementation of rams with MOSC significantly reduced creatinine and GPT compared to those supplemented with MOL or the control group. It can be concluded that feeding supplementation ration of Barki rams with MOSC can increase antibody production, WBCs, neutrophils, TAC and decreased MAD, having a positive effect on kidney function and liver enzymes, and enhances the immunity status of rams.

show abstract

Palliative effects of Moringa olifera ethanolic extract on hemato-immunologic impacts of melamine in rats

Cited by 33 publications

References 64 publications

Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis

Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis

Evaluation of Cell Viability Effects and Antioxidant Activity of Caryota urens Linn. and Couroupita guianensis aublet Leaves in a Model of Ehrlich Ascites Carcinoma as a Xenograft model

Effect of Moringa Olifera Supplementation on Immune Response, Oxidative Stress in Barki Rams

Contact Info

Product

Resources

About