Palliation of pancreatic cancer using electrolytic ablation

Wemyss‐Holden, Simon A.; Court, Fiona; Morrison, Charles; Teague, B. D.; Burrell, Aidan; Moralès, Daniel; Rodgers, Nick; Anthony, Adrian; Metcalfe, Matthew S.; Dennison, Ashley R.; Maddern, Guy J.

doi:10.1007/s00464-002-9109-y

Cited by 6 publications

(12 citation statements)

References 26 publications

(27 reference statements)

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“…However, by the 4 th post-operative day the serum amylase levels were not significantly (p > 0.05) different from the preoperative values. Previous experimental studies, reported by this group, have demonstrated that a transient hyperamylasemia is be caused by pancreatic duct cannulation alone, without electrolysis [35]. These experimental findings mirror clinical experience where diagnostic ERCP is associated with a significant increase in serum amylase concentration [9].…”

Section: Discussionmentioning

confidence: 53%

“…Mean treatment time was 21 min (range: 18-22 min). The dose of 50 C was decided after analysis of both the data from a pilot study investigating the feasibility and safety of pancreatic electrolytic ablation and preexisting dose/volume data generated from previous studies into hepatic electrolytic ablation [32,34,35].…”

Section: Methodsmentioning

confidence: 99%

“…Previous work from this group has shown that it is feasible and safe to deliver an electrolytic dose to the pancreas via the pancreatic duct [35]. A large animal study has shown that although there is a transient rise in both serum amylase and C-reactive protein there is no evidence of acute pancreatitis on clinical, biochemical, or histological parameters.…”

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confidence: 94%

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Perductal electrolytic ablation of the porcine pancreas: A minimally invasive option-studies of morbidity and mortality

et al. 2004

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This study suggests that, although there is localized pancreatic necrosis and transient hyperamylasemia, perductal pancreatic electrolytic ablation is safe, with neither generalized pancreatitis nor a systemic inflammatory response, in the medium and long term. Although performed in normal porcine pancreas, because of the absence of a large-animal model of pancreatic cancer, this study suggests that electrolytic pancreatic ablation is safe. This technique may have a role in the palliation of pancreatic cancer, especially if delivered via a minimally, invasive approach, and warrants further investigation.

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Section: Discussionmentioning

confidence: 53%

Section: Methodsmentioning

confidence: 99%

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Perductal electrolytic ablation of the porcine pancreas: A minimally invasive option-studies of morbidity and mortality

et al. 2004

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“…Previous studies have shown that per-ductal electrolytic ablation of the pancreas is both feasible and safe in the porcine model [12] . The results of this study not only support these previous fi ndings but also show that it is possible to endoscopically deliver an electrolytic ablative dose to the pancreas via the pancreatic duct, safely and with minimal short-or long-term morbidity.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to this, electrolysis has been shown to be safe in close proximity to vascular structures, which is not the case with other ablative techniques [11] . Previous experimental studies have shown that the delivery of an electrolytic dose to pancreatic tissue via a catheter inserted into the pancreatic duct is both feasible and safe in the short to long term [12] . In these studies, cannulation of the pancreatic duct was performed as an open procedure.…”

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confidence: 99%

Endoscopic Perductal Electrolytic Ablation of the Pancreas: Experimental Studies of Morbidity and Mortality

Morrison¹,

Court²,

Teague³

et al. 2005

Dig Dis

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Background: Palliation of pancreatic cancer remains the only option for the majority of patients. Palliative techniques such as surgical bypass and endoscopic retrograde cholangiopancreatography (ERCP) with stenting are not ideal. The ‘ideal’ palliative technique would combine the efficacy of surgery with the minimal complications of an endoscopic procedure. Endoscopically delivered perductal electrolytic ablation of pancreatic lesions has the potential to meet these criteria. Methods: Fifteen pigs were used. The pancreatic duct was cannulated with an electrolysis catheter. Animals were randomised to either: controls, treatment 2-week survivor or treatment 8-week survivor. An electrolytic dose was administered to the treatment animals. Post-operatively, serum amylase and leucocyte count were assessed. Pancreata were histologically examined to detect evidence of acute pancreatitis. Results: Electrolysis was well tolerated. There was no difference in post-operative hyperamylasaemia and leucocyte count between the groups. Histological examination showed inflammation at the ablation site at 2 weeks, by 8 weeks this was replaced by scarring. Conclusion: The results of this study suggest that endoscopic perductal electrolytic ablation of the pancreas is feasible and safe. Biochemical and histological findings indicate self-limiting localised inflammation of the pancreas. This technique may have a role in the palliation of pancreatic cancer and warrants further investigation.

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The lack of a systemic inflammatory response syndrome supports the safety of pancreatic electrolysis: experimental studies

Teague

Morrison

Court

et al. 2004

Journal of Surgical Research

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Palliation of pancreatic cancer using electrolytic ablation

Cited by 6 publications

References 26 publications

Perductal electrolytic ablation of the porcine pancreas: A minimally invasive option-studies of morbidity and mortality

Perductal electrolytic ablation of the porcine pancreas: A minimally invasive option-studies of morbidity and mortality

Endoscopic Perductal Electrolytic Ablation of the Pancreas: Experimental Studies of Morbidity and Mortality

The lack of a systemic inflammatory response syndrome supports the safety of pancreatic electrolysis: experimental studies

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