Palladium Toxicity in Animals and in in vitro Test Systems — An Overview

Melber, Christine; Mangelsdorf, Inge

doi:10.1007/3-540-29220-9_39

Cited by 8 publications

(8 citation statements)

References 79 publications

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“…A three-month study of palladium exposure (10–250 μg/L) through drinking water in male rats reported that palladium accumulated mainly in the kidney, but not in the liver, lung, spleen, or bones, while elimination occurred through the fecal route. 77 Another study found that palladium(II) chloride (PdCl 2 ) was poorly absorbed (<0.5%) from the digestive tract, i.e., 95% of the palladium was eliminated in the feces of rats due to nonabsorption. 78 Hence, oral administration of paracetamol (2 g/kg b.w.)…”

Section: Discussionmentioning

confidence: 99%

Biofabricated Palladium Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite Using thePunica granatum(Pomegranate) Peel Extract: Investigation of Potent In Vivo Hepatoprotective Activity against Acetaminophen-Induced Liver Injury in Wistar Albino Rats

et al. 2023

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Acute acetaminophen (APAP) toxicity is a predominant clinical problem, which causes serious liver injury in both humans and experimental animals. This study presents the histological and biochemical factor and antioxidant enzyme level changes induced by an acute acetaminophen overdose in Wistar albino rat livers to elucidate the effective hepatoprotective potential of biofabricated palladium nanoparticle-decorated reduced graphene oxide nanocomposites (rGO/PdNPs-NC) compared to silymarin. After detailed characterization of the hepatoprotective potential of the synthesized rGO/PdNPs-NC, the rats were divided into eight groups (n = 6): control group (normal saline, 1 mL/kg b.w.), silymarin, Punica granatum (pomegranate) peel extract, PdNPs, reduced graphene oxide (rGO-PG), and reduced graphene oxide palladium nanocomposites (rGO/PdNPs-NC, low and high doses) for 7 successive days. The acetaminophen (APAP)-treated group was administered a single dose of acetaminophen (2 g/kg b.w.) on the 8th day. The histopathological results showed that the acetaminophen overdose group exhibited massive intrahepatic hemorrhagic necrosis around the centrilobular region with hepatocytes with vacuolization and swollen cytoplasm found in the liver architecture. This hepatopotential was further assessed by various biochemical parameters such as SGOT, SGPT, ALB, ALP, LDH, direct bilirubin, total bilirubin, and total protein. Also, the antioxidant parameters such as SOD, CAT, MDA, GSH, GRD, and GST were assayed. Rats of groups 7 and 8 showed a significant decrease in SGOT, SGPT, ALP, LDH, direct bilirubin, and total bilirubin (p < 0.001), while a significant increase in the final total protein and ALB as compared to group 2 rats (p < 0.001) was observed. The antioxidant parameters exhibited that rats of groups 7 and 8 showed a significant (p < 0.001) increase in the level of SOD, CAT, GSH, GRD, and GST without affecting the MDA as compared to group 2 rats. Also, the hepatoprotective potential of rGO/PdNPs-NC (low and high doses) was comparable to that of the standard reference drug silymarin. The present study reveals that the rGO/PdNPs-NC possesses significant hepatoprotective activity and acts as an effective and promising curative agent against acetaminophen-induced hepatotoxicity.

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Section: Discussionmentioning

confidence: 99%

Biofabricated Palladium Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite Using thePunica granatum(Pomegranate) Peel Extract: Investigation of Potent In Vivo Hepatoprotective Activity against Acetaminophen-Induced Liver Injury in Wistar Albino Rats

et al. 2023

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“…We failed to find a significant association between Pd sensitization and occupation; however, health care workers and technicians were more sensitized to Pd than clerks. This major prevalence might be explained by considering that Pd is used in dental amalgams and dental alloys, surgical instruments, and other high-quality metallic items 6,7 . González-Ruiz et al 33 reported a higher prevalence of Pd sensitization in subjects with occupational dermatitis in Spain, but they did not identify a specific occupational group.…”

Section: Discussionmentioning

confidence: 99%

“…Palladium (Pd) has been used to replace Ni in metal alloys used in dentistry, jewelry, and spectacles 6 . Moreover, Pd is an excellent catalyst for hydrogenation and dehydrogenation reactions and is widely used in high-temperature solders, in the automotive industry, indelible ink, telecommunication, and production of surgical instruments 7 . The application of this metal in various industrial fields has led to a significant increase in exposure to Pd and a potential rise in allergenic effects.…”

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confidence: 99%

Patch Test Positivity to Palladium: A 5-Year Retrospective Study in Triveneto Region, Italy

Vergara¹,

Michieli²,

Rui³

et al. 2021

Dermatitis

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Background: The use of palladium (Pd) is increasing in metal objects after the banning of nickel in items in prolonged contact with the skin. The properties of Pd make this metal useful in various industrial fields.Objective: The aim of the study was to evaluate the prevalence of Pd sensitization in patients who underwent patch tests for suspected allergic contact dermatitis in the Triveneto region from 2013 to 2018.Methods: A total of 4816 patients with symptoms and/or signs of suspected contact allergic dermatitis were patch tested. Individual characteristics were assessed using a standardized questionnaire.Results: The overall prevalence of Pd sensitization was 7.6% and 10.8% using PdCl 2 1% or 2% petrolatum, respectively, with a higher prevalence in women (odds ratio, 2.6; 95% confidence interval, 1.9-3.7) and in 26-to 55-year-old patients. Monosensitization occurred in 1%-1.5% of the patients tested. Health care workers and technicians were more sensitized to Pd than clerks, but the data did not reach statistical significance.Conclusions: Palladium sensitization was high, but it was mainly associated with nickel sensitization. A possible occupational role was found for workers with potential contact with Pd-containing objects, but more data are needed to reach statistical significance.

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“…49,50 The ability of palladium to undergo complexation with different biomolecules raises serious concerns, even when present in minute concentrations. 51,52 Thus, it is quite essential but a challenging task to design a chemosensor that can selectively detect Pd ions.…”

Section: Introductionmentioning

confidence: 99%

A Zn-MOF functionalized with alkyne groups: ultrasensitive detection of Cu⁺ and Pd²⁺ ions in aqueous medium

Aashish,

Gupta,

Gupta

2023

Sens. Diagn.

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Palladium Toxicity in Animals and in in vitro Test Systems — An Overview

Cited by 8 publications

References 79 publications

Biofabricated Palladium Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite Using thePunica granatum(Pomegranate) Peel Extract: Investigation of Potent In Vivo Hepatoprotective Activity against Acetaminophen-Induced Liver Injury in Wistar Albino Rats

Biofabricated Palladium Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite Using thePunica granatum(Pomegranate) Peel Extract: Investigation of Potent In Vivo Hepatoprotective Activity against Acetaminophen-Induced Liver Injury in Wistar Albino Rats

Patch Test Positivity to Palladium: A 5-Year Retrospective Study in Triveneto Region, Italy

A Zn-MOF functionalized with alkyne groups: ultrasensitive detection of Cu⁺ and Pd²⁺ ions in aqueous medium

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Palladium Toxicity in Animals and in in vitro Test Systems — An Overview

Cited by 8 publications

References 79 publications

Biofabricated Palladium Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite Using thePunica granatum(Pomegranate) Peel Extract: Investigation of Potent In Vivo Hepatoprotective Activity against Acetaminophen-Induced Liver Injury in Wistar Albino Rats

Biofabricated Palladium Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite Using thePunica granatum(Pomegranate) Peel Extract: Investigation of Potent In Vivo Hepatoprotective Activity against Acetaminophen-Induced Liver Injury in Wistar Albino Rats

Patch Test Positivity to Palladium: A 5-Year Retrospective Study in Triveneto Region, Italy

A Zn-MOF functionalized with alkyne groups: ultrasensitive detection of Cu+ and Pd2+ ions in aqueous medium

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A Zn-MOF functionalized with alkyne groups: ultrasensitive detection of Cu⁺ and Pd²⁺ ions in aqueous medium