Palladium coordination compounds as anti-viral, anti-fungal, anti-microbial and anti-tumor agents

New Look on 3-Hydroxyiminoflavanone and Its Palladium(II) Complex: Crystallographic and Spectroscopic Studies, Theoretical Calculations and Cytotoxic Activity

“…Palladium complexes have been studied extensively, based on their structural analogy with platinum complexes. A variety of Pd(II) complexes have shown promising activity as antitumor, antiviral, antimalarial, antifungal and antimicrobial agents [4][5][6]. However, most studies were not very encouraging because the Pd(II) complexes generally showed lower antitumor activity than cisplatin.…”

Síntese e caracterização de um novo complexo bimetálico de Pd(II) contendo o antibiótico oxitetraciclina

“…Pela análise do espectro de infravermelho sugerimos que o íon paládio(II) coordena-se no anel A, mais especificamente nos oxigênios da amida e da hidroxila vizinha no anel A e aos oxigênios da carbonila em C11 e da hidroxila em C12. No que se refere aos complexos de paládio, estes têm sido investigados quanto ao seu potencial biotecnológico, principalmente como novos agentes antibacterianos e antitumorais [5]. …”

A New Complex of Palladium(II) With 2-Furoic Hydrazide: Synthesis, Characterization, Theoretical Calculations and Biological Studies

“…9 On the other hand, palladium complexes have been obtained aiming to produce drugs, due to its chemical similarity with platinum, and the fact that they showed excellent antitumoral and anti infective activities in vitro and in vivo. 12 For example, our research group showed that the palladium(II) complex of tetracycline is 16 times more potent than free tetracycline against E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. 13 In addition, this complex displays a significant cytotoxic activity.…”