A New Complex of Palladium(II) With 2-Furoic Hydrazide: Synthesis, Characterization, Theoretical Calculations and Biological Studies

Abstract

Abstract.A new complex of palladium was isolated with 2-furoic hydrazide (FH) and characterized by spectroscopic methods. The results show that the ligand is coordinated to palladium by the basic nitrogen of NH 2 group and has a general structure of type cis-[Pd(FH) 2 Cl 2 ]. The structure of palladium(II) complex was optimized and theoretical data show good agreement with the experimental results. The cytotoxic activity was evaluated in a chronic myelogenous leukemia cell line, which revealed that the compound is less active than cisplatin or carboplatin. At 300 g mL −1 , the complex presented antimicrobial activity more efficient than ampicillin, chloranfenicol and kanamicyn. (doi: 10.5562/cca2151)

Novel Structures of Functionalized Graphene Oxide with Hydrazide: Characterization and Bioevaluation of Antimicrobial and Cytocompatibility Features

“…The 4-(benzensulfonamido)benzoic acid hydrazide was used as an intermediate compound in the synthesis of pharmacologically active N-[4-[(phenylcarbamoyl) amino]phenyl]benzenesulfonamide derivatives [26]. The 2-furancarboxylic acid hydrazide was the key intermediate for the synthesis of a new Pd complex with antibacterial activity [27].…”

Synthesis, Spectroscopic, Antimicrobial Activity and Computational Studies of Some Homoleptic and Heteroleptic Metal(II) Complexes of 2‐Furoic Acid Hydrazone

“…They are privileged molecular nuclei that enjoy great applicability as precursors to organic and inorganic drug‐molecules . Reports of investigations involving biological (antibacterial, antifungal, antiviral, antitumoral, etc) activities of hydrazones are replete in literature . They also have good ligating capabilities towards main group and transition‐metal ions, and as such, have been employed in analytical chemistry, for micro‐scale extraction, quantitative determination of metal ions in aqueous media, and in the synthesis of structurally interesting compounds …”

“…[1,2,5] Reports of investigations involving biological (antibacterial, antifungal, antiviral, antitumoral, etc) activities of hydrazones are replete in literature. [1,6,7] They also have good ligating capabilities towards main group and transition-metal ions, [5,[8][9][10][11] and as such, have been employed in analytical chemistry, for micro-scale extraction, quantitative determination of metal ions in aqueous media, [12][13][14] and in the synthesis of structurally interesting compounds. [10][11][12][15][16][17] Many 2,2'-bipyridines are known to form stable complexes with interesting structural and chemical properties, [18][19][20][21][22][23] including exhibition of intense luminescence due to metal-ligand charge transfer and conjugated aromatic system.…”

Síntese, caracterização e estudos biológicos envolvendo complexos de cobre(II) contendo hidrazidas e ligantes N,N-doadores

“…Hidrazidas (R-CO-NH-NH 2 ) e derivados têm despertado grande interesse, pois apresentam uma ampla variedade de propriedades biológicas, incluindo antimicobacteriana, antifúngica, antibacteriana, antioxidante, anti-inflamatória, tripanocida e antitumoral, dentre outras NARANG, et al, 2012;BINGUL, 2016). Estudos publicados pelo nosso grupo de pesquisa relataram que os complexos metálicos contendo hidrazidas apresentam um potencial antitumoral, sendo que os ensaios conduzidos in vitro mostraram que os mesmos são mais ativos que os fármacos empregados na clínica médica para o tratamento do câncer (FONTES et al, 2004;SOUZA et al, 2013;RODRIGUES et al, 2015).…”