Palladium‐Catalyzed Tandem γ‐Arylation/Aromatization of Cyclohex‐2‐En‐1‐One Derivatives: A Route to 3,4‐Dihydroanthracen‐1(2H)‐Ones

Abstract

An intramolecular palladium‐catalyzed tandem γ‐arylation/aromatization reaction of cyclohex‐2‐en‐1‐one derivatives was developed. This work provides a simple and efficient approach for the construction of substituted 3,4‐dihydroanthracen‐1(2H)‐ones in good yields with a broad substrate scope.

Palladium-catalyzed direct γ-C(sp3)–H arylation of β-alkoxy cyclohexenones: reaction scope and mechanistic insights

“…8 More recently, Pd-catalyzed exocyclic γ-C(sp 3 )-arylations of unactivated cyclic electron-deficient enones were achieved by a ligand control strategy 9 (Scheme 1a, C) or an intramolecular approach. 10 However, the method for direct γ-C(sp 3 )-arylation of unactivated electron-rich enones is extremely limited.…”