Palladium-Catalyzed γ-C–H Arylation of Unsaturated Carbonyl Compounds: An Emerging Remote Buchwald–Hartwig–Miura Arylation

Abstract

As an important complement to Buchwald-Hartwig-Miura arylation, Pd-catalyzed -C-H including -C(sp3)-H and -C(sp2)-H arylations provide a more direct way to install an aryl group on less reactive -site of the unsaturated carbonyls, attracting considerable interests from chemistry community in recent years. The review summarizes the applications of this method in both cyclic and linear unsaturated carbonyls (aldehydes, ketones, esters, amide, and nitriles), as well as in the total synthesis of natural products, natural products skeletons, and bioactive analogues.