Palladium‐Catalyzed Novel C(formyl)‐C(aryl)/C(aryl)‐N(amine) Coupling Sequence Between 2‐(Methylamino)nicotinaldehyde and 3‐Bromo‐2‐chlorothiophene: An Efficient Construction of 4‐Pyridone Fused Hybrid Scaffolds

Abstract

An unique cyclization reaction between very simple starting materials such as 2‐ (methylamino)nicotinaldehyde and 3‐bromo‐2‐chlorothiophene has been reported. This strategy offers a facile access to a plethora of thieno[2,3‐b][1,8]naphthyridin‐4(9H)‐one derivatives, which are highly anticipating in pharmaceutical science as potential biologically active candidates.