A novel series of hybrid 2-substituted ((pyrimidin-2-yl)hydrazinyl)thiazolidin-4-one derivatives were synthesized by means of aromatic nucleophilic displacement of chlorine atoms of 2,4,6-trichloro pyrimidine. Synthesis of some novel 2-(2-(6-morpholino-4-substituted(phenyl amino)pyrimidin-2-yl)hydrazinyl)thiazol-4(5H)-one derivatives have been carried out by the displacement of chlorine atoms on the basis of functionality concept on varying conditions. The synthesized hydrazinyl thiazolidin-4-one pyrimidine derivatives were evaluated for their expected antimicrobialactivity; where, the majority of these compounds showed potent antibacterial and antifungal activities against the tested strains of bacteria and fungi. Afforded title analogs were subsequently characterized by elemental analysis, IR, 1 H NMR, 13 C NMR, Mass spectroscopy. SAR and HOMO-LUMO studies were also carried out for confirming the structure biological activity. Thus, these studies suggested that hydrazinyl pyrimidine derivatives bearing thiazolidinone moiety are interesting scaffolds for the development of novel antimicrobial agents.

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In present scenario, innovative carbon disulfide‐involving multicomponent protocols are extremely advantageous for practical and efficient construction of acyclic as well as heterocyclic building blocks. Carbon disulfide is well recognized synthetic component and has achieved the desirability of scientific community for the preparation of a variety of highly functionalized organic scaffolds. Carbon disulfide involving MCRs mostly advantage from other features such as bond‐forming efficiency, resource effectiveness, the use of easily obtainable starting compounds, and atom‐economy, which make these protocols useful environmentally benign alternatives, in care with the greener way in which organic chemistry is going on. In this review article, we have discussed the noteworthy topical advances in the promising region of carbon disulfide‐involving multicomponent reactions. It highlight the prospects and confronts, emphasizing the diverse approaches established previously.

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