Palladium-Assisted Routes to Nucleosides

Abstract

A. Palladium Compounds and ComplexesOrganic synthesis generally makes use of palladium compounds in either the Pd(0) or Pd(II) oxidation state. Palladium(II) salts may be used either as stoichiometric reagents or as catalysts, while palladium(0) complexes are used only as catalysts.

1,3-Dipolarna cikloadicija (I. dio): Dobivanje 1,2,3-triazolnih derivata u nukleozidnoj kemiji

“…Tsuji-Trostova reakcija, također je pokazala velik potencijal zbog široke primjene i relativno jednostavnih reakcijskih uvjeta. 3 Paladijem katalizirane reakcije mogu se provoditi i s različi-tim organometalnim spojevima kao što su organokositrovi (Stille), 3,8 organocinkovi (Negishi), 9 organosilicijevi (Hiyama) 10 ili organoborovi spojevi (Suzuki). 3 Osnovni razlog za veliku upotrebu paladija u sintezi je to što se stvaranjem nove veze ugljik-ugljik pruža mogućnost novih strukturnih transformacija molekule.…”

“…Paladijem katalizirane reakcije mogu se provoditi i s različi-tim organometalnim spojevima kao što su organokositrovi (Stille), 3,8 organocinkovi (Negishi), 9 organosilicijevi (Hiyama) 10 ili organoborovi spojevi (Suzuki).…”

Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives

“…1 Some nucleoside analogues substituted at various positions on the heterocycle, are known to have potent biological properties and have been investigated, for instance, as antiviral agents (against HSV, VZV, CMV, HIV, HBV and HCV), non-radioactive fluorescent labels for DNA and as anticancer drugs. 2 Extensive studies have been carried out on 5-substituted uracil analogues for use in cancer and viral chemotherapy, as enzyme inhibitors. 3 Notable among them are 5-fluorouracil (5-FU) and the corresponding 2'-deoxyribonucleoside (FdU) which have been used in cancer chemotherapy for decades.…”

Simple method for fast deprotection of nucleosides by triethylamine-catalyzed methanolysis of acetates in aqueous medium

“…[1][2][3][4] Consequently, improved and abbreviated synthesis of modified nucleosides from readily available precursors is of considerable interest. [5][6][7][8][9] However, nucleosides are challenging synthetic substrates as they contain several functionalized groups that must be chemically differentiated for successful transformations. Therefore, multi-step synthesis frequently requires the introduction of protective groups and their subsequent removal.…”