Palicourea tomentosa (Aubl.) Borhidi: Microscopy, chemical composition and the analgesic, anti-inflammatory and anti-acetylcholinesterase potential

Formagio, Anelise Samara Nazari; Vilegas, Wagner; Volobuff, Carla Roberta Ferreira; Kassuya, Cândida Aparecida Leite; Almeida, Valter Paes de; Budel, Jane Manfron; Pereira, Zefa Valdevina; Cabral, Márcia Regina Pereira; Sarragiotto, María Helena

doi:10.1016/j.jep.2022.115050

Cited by 3 publications

(3 citation statements)

References 56 publications

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“…The chemical composition of the crystals occurring in plants can be identified using EDS 40 , 41 . In the present study, four morphotypes of calcium oxalate crystals were found in various tissues of V. album subsp.…”

Section: Resultsmentioning

confidence: 99%

Investigations on the morpho-anatomy and histochemistry of the European mistletoe: Viscum album L. subsp. album

Almeida

Monchak

Batista

et al. 2023

Sci Rep

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Viscum album L. (Santalaceae) is an important medicinal plant traditionally used to treat several diseases, including cancer therapy. This paper provides detailed morpho-anatomical characteristics of the leaves, stems and berries of Viscum album subsp. album growing as hemi-parasite on the branches of Malus domestica (Suckow) Borkh. (Rosaceae) to aid species identification and botanical characterization. Additionally, for the first time, microchemical analyses of all tissues and Energy Dispersive X-Ray Spectroscopy analyses of the calcium oxalate crystals are provided for the first time. The plant features leathery presents green leaves with parallel veins, small yellow unisexual flowers in 3-flowered cymes, and the dioecious inflorescences usually consist of three flowers, with female flowers generating white fleshy berries, in which a seed is embedded in the mucilaginous mesocarp, normally containing two embryos. Anatomically, the analyzed leaves were isobilateral and amphistomatic, and showed straight anticlinal epidermal cell walls, thick cuticles with epicuticular wax crystalloids, and paracytic stomata. The midrib is flat on both sides and has a single vascular bundle, whereas the strongly shortened petiole is concave-convex in shape and contains five bundles. The stems show a primary structure with a ring of nine vascular bundles enclosing the pith. Calcium oxalate druses and cubic and quadrangular prisms were observed in different plant parts. The results of this study provide new microscopy information that can help in the authentication of mistletoe raw materials.

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Section: Resultsmentioning

confidence: 99%

Investigations on the morpho-anatomy and histochemistry of the European mistletoe: Viscum album L. subsp. album

Almeida

Monchak

Batista

et al. 2023

Sci Rep

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“…These results correspond with the micromorphology and histochemical findings of the present study. Chemical studies carried out by our group have revealed the presence of indole alkaloids, such as vincosamide in P. leiocarpa [11], tryptamine-related alkaloids in P. brachybotrya [34] and vomifoliol and loliolide in Palicourea tomentosa (synonym Psychotria poeppigiana) [35].…”

Section: Discussionmentioning

confidence: 99%

“…However, phytochemical and biological information from only two groups of P. capillacea has been reported in the literature [3,4]. Palicourea tomentosa, Psychotria leiocarpa, P. nuda, P. nemorosa, P. brachypoda, P. colorata and P. myriantha have been reported to have anti-inflammatory and analgesic effects and impair learning and memory acquisition [11,12,35,[43][44][45]. However, only two studies of P. capillacea in the literature have reported phytochemical and biological information [3,4].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Description of the Anatomy and Histochemistry of Psychotria capillacea (Müll. Arg.) Standl. and an Investigation into Its Anti-Inflammatory Effects in Mice and Role in Scopolamine-Induced Memory Impairment

Formagio,

Vilegas,

Kassuya

et al. 2024

Pharmaceuticals

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Species of the genus Psychotria are used in popular medicine for pain, inflammatory symptoms, and mental disorders. Psychotria capillacea (Müll. Arg.) Standl. (Rubiaceae) is commonly known as coffee and some scientific studies have demonstrated its therapeutic potential. The goal of this study was to investigate the anti-inflammatory and neuroprotective effects, and acetylcholinesterase (AChE) inhibitory activity of a methanolic extract obtained from leaves of P. capillacea (MEPC), as well as the micromorphology and histochemistry of the leaves and stems of this plant. In addition, the MEPC was analyzed by UHPLC-MS/MS and the alkaloidal fraction (AF) obtained from the MEPC was tested in a mouse model of inflammation. MEPC contained three indole alkaloids, one sesquiterpene (megastigmane-type) and two terpene lactones. MEPC (3, 30 and 100 mg/kg) and AF (3 and 30 mg/kg) were evaluated in inflammation models and significantly inhibited edema at 2 h and 4 h, mechanical hyperalgesia after 4 h and the response to cold 3 h and 4 h after carrageenan injection. Scopolamine significantly increased the escape latency, and reduced the swimming time and number of crossings in the target quadrant and distance, while MEPC (3, 30 and 100 mg/kg), due to its neuroprotective actions, reversed these effects. AChE activity was significantly decreased in the cerebral cortex (52 ± 3%) and hippocampus (60 ± 3%), after MEPC administration. Moreover, micromorphological and histochemical information was presented, to aid in species identification and quality control of P. capillacea. The results of this study demonstrated that P. capillacea is an anti-inflammatory and antihyperalgesic agent that can treat acute disease and enhance memory functions in mouse models.

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Morpho-anatomy and histochemistry of European mistletoe (Viscum album L. subsp. album), a semi-parasite growing on Malus domestica

Almeida

Monchak

Batista³

et al. 2022

Preprint

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This paper provides detailed morpho-anatomical characteristics of the leaves, stems and berries of Viscum album L. subsp. album (Santalaceae) growing on the branches of Malus domestica. Additionally, microchemical analyses of all tissues and Energy Dispersive X-Ray Spectroscopy (EDS) analyses of the calcium oxalate crystals are provided for the first time. The plant grows as a semi-parasite on the branches of host trees and shrubs; it develops as dichasium with pseudo-dichotomous branching stems and well-developed green leaves with parallel veins; the dioecious inflorescences usually consist of three flowers, with female flowers generating white fleshy berries, in which a seed is embedded in the mucilaginous mesocarp, normally containing two embryos. The analyzed leaves were isobilateral, amphistomatic, and showed straight anticlinal epidermal cell walls, thick cuticles with epicuticular wax crystalloids, and paracytic stomata. The midrib is flat on both sides and has a single vascular bundle, whereas the petiole is concave-convex in shape and contains five bundles. The stems show a primary structure with a ring of nine vascular bundles enclosing the pith. Calcium oxalate druses and cubic and quadrangular prisms were observed in different parts of the plant. The microscopic features of the tissues and structures are illustrated with light and scanning electron micrographs.

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Palicourea tomentosa (Aubl.) Borhidi: Microscopy, chemical composition and the analgesic, anti-inflammatory and anti-acetylcholinesterase potential

Cited by 3 publications

References 56 publications

Investigations on the morpho-anatomy and histochemistry of the European mistletoe: Viscum album L. subsp. album

Investigations on the morpho-anatomy and histochemistry of the European mistletoe: Viscum album L. subsp. album

A Comprehensive Description of the Anatomy and Histochemistry of Psychotria capillacea (Müll. Arg.) Standl. and an Investigation into Its Anti-Inflammatory Effects in Mice and Role in Scopolamine-Induced Memory Impairment

Morpho-anatomy and histochemistry of European mistletoe (Viscum album L. subsp. album), a semi-parasite growing on Malus domestica

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