Palatal myoclonus: Algorithm for management with botulinum toxin based on clinical disease characteristics

Sinclair, Catherine F.; Gurey, Lowell E.; Blitzer, Andrew

doi:10.1002/lary.23485

Cited by 38 publications

(31 citation statements)

References 17 publications

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“…BoNT injections have been used for a long time in the treatment of palatal and other forms of segmental myoclonus . Injections into the tensor‐veli‐palatini usually improves clicking sound, whereas an injection into the medial uvula (levator‐veli‐palatini) tends to control palatal movements . Risk of dysphagia associated with BoNT injections can be minimized by starting with a very low dose and, if no adverse effects are encountered, gradually increasing it in subsequent visits.…”

Section: New Treatments and Discoveriesmentioning

confidence: 99%

Therapeutic Developments for Tics and Myoclonus

Jankovic

2015

Movement Disorders

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Tics and myoclonus are phenomenologically similar given that both are jerk-like movements, but, in contrast to myoclonus, tics are often preceded by premonitory sensations and are typically associated with a variety of behavioral comorbidities, including attention deficit and obsessive-compulsive disorder. There are many other clinical features that help differentiate these two hyperkinetic disorders. Whereas behavioral and antidopaminergic therapies are most effective in the management of tics, clonazepam, other anticonvulsants, and serotonergic drugs are often used to control myoclonic movements. Botulinum toxin may also be helpful in focal tics and in segmental forms of myoclonus. DBS plays an increasingly important role in the treatment of these disorders, particularly when they are generalized and are disabling despite optimal medical therapy.

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Section: New Treatments and Discoveriesmentioning

confidence: 99%

Therapeutic Developments for Tics and Myoclonus

Jankovic

2015

Movement Disorders

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“…We read with great interest the article by Sinclair et al 1 published in the May 2014 issue of The Laryngoscope. Palatal myoclonus is a rare disorder that is characterized by involuntary rhythmic contraction of the palatal musculature and is a potentially treatable cause of objective tinnitus.…”

Section: Letter To the Editormentioning

confidence: 99%

In reference to palatal myoclonus: Algorithm for management with botulinum toxin based on clinical disease characteristics

Özdoğan¹,

Genç²,

Özel³

et al. 2015

The Laryngoscope

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“…Palatal tremor clinically manifests itself as a sensation of palatal not-willed movements together with rhinolalia or without it (in 20% of patients), ear clicks (in 46.7% of patients), or both (in 33.3% of patients) [13]. When examined, 53.3% of patients show throat muscle movements synchronized with those of the palate [13]. Palatal tremor also takes place while the patient is asleep, yet disappears during swallowing and in the dorsal position.…”

Section: Introductionmentioning

confidence: 99%

“…Attempts to treat such patients with anxiolytic and anticonvulsive drugs, as well as surgical treatment and masking white noise application, appeared to be inefficient. Some researchers [11,15,13] shared their positive experience of injecting botulinum toxin in case of palatal myoclonus. Botulinum toxin inhibits release of acetylcholine from presynaptic nerve terminals thus causing muscle "chemical denervation" which lasts several weeks.…”

Section: Introductionmentioning

confidence: 99%

Myoclonus of the Auricular Muscles as the Cause of Objective Tympanophonia

Vicheva¹

2018

OOAJ

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The objective of the present article was to systematize the available data on the etiology, pathogenesis, clinical features, diagnostics and treatment of muscular tympanophonia. The common sourse of muscular tympanophonia is the tremor (myoclonus) of the soft palate or muscles of auditory ossicles. Sometimes this condition can be a consequence of myoclonus of the external ear muscles. Pharmacotherapy of muscular tympanophonia does not invariably result in the favourable outcome. The authors describe a rare observation of objective tympanophonia attributable to myoclonus of auricular muscle. Abbreviations: MEM: Middle Ear Myoclonus. Muscle tympanophony typically results from palatal tremor (myoclonus) or middle ear myoclonus. However there are a few descriptions of tympanophony associated with eyelid movement [7], ear outer muscle myoclonus (M. auricularis anterior, superior, posterior), and head Editorial Volume 3 Issue 2

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Palatal myoclonus: Algorithm for management with botulinum toxin based on clinical disease characteristics

Abstract: Palatal myoclonus can present with tinnitus or patient-perceived palatal movements. Management with botulinum toxin can be tailored to address the muscles contributing to the predominant presenting symptoms.

Cited by 38 publications

References 17 publications

Therapeutic Developments for Tics and Myoclonus

Therapeutic Developments for Tics and Myoclonus

In reference to palatal myoclonus: Algorithm for management with botulinum toxin based on clinical disease characteristics

Myoclonus of the Auricular Muscles as the Cause of Objective Tympanophonia

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