Palatal mucormycosis: a rare clinical dilemma

Shetty, Smitha Sammith; Punnya, V.A.

doi:10.1111/j.1752-248x.2008.00025.x

Cited by 14 publications

(8 citation statements)

References 9 publications

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“…There should be close monitoring of serum electrolytes, as polyenes are known to cause potassium imbalance [12]. Data from comparison of lipid complex amphotericin B and deoxycholate amphotericin B showed improved survival rates and less side effects with lipid complex amphotericin B [13]. Angioinvasion, thrombosis, and tissue necrosis of Mucor leads to poor penetration of antifungal agents at the site of infection and compromises the efficacy of the same [14].…”

Section: Discussionmentioning

confidence: 98%

“…Nonconventional therapeutic agents such as antihypoglycemics, iron chelating agents, statins, granulocyte transfusions, cytokines, and hyperbaric oxygen have increased the survival rates to 94% [13]. Deferasirox (15-20 mg/kg daily), an approved oral iron chelator, has fungicidal effects and interacts synergistically with liposomal amphotericin B against Glomeromycota [15].…”

Section: Discussionmentioning

confidence: 99%

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Rhinomaxillary osteomyelitis due to mucormycosis in an immunocompromised geriatric patient

Singh¹,

Pandey²,

Agrawal³

2015

Egyptian Journal of Oral & Maxillofacial Surgery

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Mucormycosis is a type of an opportunistic fungal infection, which most commonly involves structures in the maxillofacial region, such as the paranasal air sinuses, maxilla, and orbit and in advanced stages it may affect the brain. The most common route of its entry is through inhalation. A common predisposing condition is diabetes mellitus, leading to an immunocompromised state. We present a case of a 63-year-old female patient with widespread maxillary osteomyelitis following teeth extraction, which was later diagnosed as mucormycosis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Rhinomaxillary osteomyelitis due to mucormycosis in an immunocompromised geriatric patient

Singh¹,

Pandey²,

Agrawal³

2015

Egyptian Journal of Oral & Maxillofacial Surgery

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“…Differential diagnosis of destructive lesions of the palate and maxilla should include squamous cell carcinoma, nasopharyngeal carcinoma, peripheral T-cell lymphoma (formerly termed midline lethal granuloma), chronic granulomatous diseases like tuberculosis, tertiary syphilis, wegener's granulomatosis and other deep fungal infection. 4 , 8 , 9 , 18 , 22 …”

Section: Discussionmentioning

confidence: 99%

“… 7 Rhinocerebral form of mucormycosis frequently presents with oral manifestations and may lead to considerable dilemma in clinicians unfamiliar with this entity, which in turn may worsen the prognosis for the patient. 8 …”

Section: Introductionmentioning

confidence: 99%

Mucormycosis of the Hard Palate Masquerading As Carcinoma

Manjunatha

Das

Sutariya

et al. 2012

Clinics and Practice

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A growing number of medically compromised patients are encountered by dentists in their practices. Opportunistic fungal infections such as mucormycosis usually occur in immunocompromised patients but can infect healthy individuals as well. Mucormycosis is an acute opportunistic, uncommon, frequently fatal fungal infection, caused by a saprophytic fungus that belongs to the class of phycomycetes. Among the clinical differential diagnosis we can consider squamous cell carcinoma. Such cases present as chronic ulcers with raised margins causing exposure of underlying bone. There is a close histopathological resemblance between mucormycosis and aspergillosis. Microscopically, aspergillosis has septate branching hyphae, which can be distinguished from mucormycotic hyphae by a smaller width and prominent acute angulations of branching hyphae. A definitive diagnosis of mucormycosis can be made by tissue biopsy that identifies the characteristic hyphae, by positive culture or both. The culture of diseased tissue may be negative and histopathologic examination is essential for early diagnosis. Mucormycosis was long regarded as a fatal infection with poor prognosis. However with early medical and surgical management survival rates are now thought to exceed 80%. In the present case, the fungus was identified by hematoxylin and eosin stain and confirmed by Grocott's silver methenamine special staining technique. Removal of the necrotic bone, which acted as a nidus of infection, was done. Post-operatively patient was advised an obturator to prevent oronasal regurgitation. Since mucormycosis occurs infrequently, it may pose a diagnostic and therapeutic dilemma for those who are not familiar with its clinical presentation.

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“…Rhinocerebral mucormycosis is the most recognized form of this disease, due to its severity, and oral manifestations are usually the first clinical signs (4). This invasive, opportunistic fungal infection is usually seen in immunocompromised patients, and particularly in the setting of diabetes or immune deficiency.…”

Section: Eromyces(3)mentioning

confidence: 99%

Fatal Attraction! Fungus and Man

Shetty¹,

Hegde

Vinod³

et al. 2014

Int J Oral-Med Sci

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Mucormycosis is a rapidly progressive disease with an acute course, and represents a classic nosocomial condition. The prognosis is usually poor, with high mortality rates that are influenced by the timeliness of diagnosis and, above all, by the underlying status of the patient. This fungal infection commonly occurs in diabetics, immunocompromised hosts, patients with leukemia, lymphoma, multiple myeloma, septicemia, hepatitis, cirrhosis, or renal failure, as well as patients receiving chemotherapy or steroids. Intravenous drug abusers are also at risk. Early detection and treatment are key elements for patient survival. This article describes a case of mucormycosis affecting the palate in an elderly patient with uncontrolled diabetes mellitus.

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Palatal mucormycosis: a rare clinical dilemma

Cited by 14 publications

References 9 publications

Rhinomaxillary osteomyelitis due to mucormycosis in an immunocompromised geriatric patient

Rhinomaxillary osteomyelitis due to mucormycosis in an immunocompromised geriatric patient

Mucormycosis of the Hard Palate Masquerading As Carcinoma

Fatal Attraction! Fungus and Man

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