Paired measurements of quantitative hepatitis B virus DNA in saliva and serum of chronic hepatitis B patients: implications for saliva as infectious agent

Transmission of hepatitis B by human bite—Confirmation by detection of virus in saliva and full genome sequencing

“…The presence of hepatitis B virus (HBV) DNA in saliva of carriers of the virus and its correlation with the serum HBV DNA level was nicely described in a recent article in this journal (van der Eijk et al, 2004). The finding has important implication in the infectivity of saliva in patients with HBV infection and offer further insight in it being an alternative route of transmission of the virus.…”

“…A recent study demonstrated that the HBV could be detected in the saliva of between 42% and 80% of chronic hepatitis B (CHB) patients (van der Eijk et al, 2004). Paired quantitative measurements of HBV DNA showed correlation between the levels of HBV DNA in saliva and serum in these patients.…”

Reverse vertical transmission of hepatitis B virus (HBV) infection from a transfusion-infected newborn to her mother

“…She reported that when her daughter was approximately 1 year old (winter 2009-2010) she presented dry skin and crevices of her hands. It has been previously reported that saliva and urine from chronic HBV infected individuals contain viral DNA and can be infectious [9][10][11][12][13]. Saliva was likely partially contaminated with serum when the child's teeth were coming out and saliva exchange might have taken place during kissing.…”

Decontamination of orthodontic bands following size determination and cleaning

“…12 The infective dose of HBV has been estimated at 20-1000 geq. The study by van der Eijk et al 12 also showed infected patients to have a median HBV DNA level in serum of 2.10610 5 genome equivalents per ml (geq/ml), ranging from 373 to 4.13610 9 geq/ml. By comparison, the median HBV DNA level in saliva was much lower, at 2.27610 4 geq/ml, and ranged from undetectable to 9.25610 6 geq/ml.…”