Painful scrotal dermatitis secondary to topical 5-fluorouracil

5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review

“…Except for the site described in this case, erythema can also occur in other sites, such as the scrotum: a 70-year-old man had a painful, burning and itchier rash on the scrotum that appeared 8 days after he started using 5% 5-FU cream to treat actinic keratosis twice daily. [ 35 ] Scrotal skin aspiration biopsy histopathology shows interfacial dermatitis with keratosis, epidermal atrophy, interfacial vacuoles, and occasionally basal keratinocyte necrosis. The rash was subsidence by taking prednisone and using betamethasone topicality for 2 weeks.…”