Painful interactions: Microbial compounds and visceral pain

Thiel, Isabelle van; Botschuijver, Sara; Jonge, Wouter J. de; Seppen, Jurgen

doi:10.1016/j.bbadis.2019.165534

Cited by 23 publications

(17 citation statements)

References 213 publications

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“…We also found a higher abundance of Dialister in HNC patients who had voice/ speech difficulty than in patients without voice/speech difficulty ( Figure S1C). Pain could be directly or indirectly induced by microbial metabolites, neuroactive molecules, cell wall components, and proteins (van Thiel et al, 2020). Symptoms, such as voice/speech difficulty and pain, could hardly be triggered by one or two kinds of oral bacterial microbes.…”

Section: Discussionmentioning

confidence: 99%

Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

Zuo

Zhao

et al. 2020

Front. Cell. Infect. Microbiol.

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This study explored the association between oral microbes and head and neck cancer (HNC) as well as symptoms related to patients with HNC before surgical treatment. Fiftysix patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, and symptom data were collected. Salivary samples were collected to determine the microbial characteristics using 16S rRNA gene sequencing. Patients with HNC presented increased Capnocytophaga abundances. The oral microbial markers as Capnocytophaga (area under the curve=0.81) achieved a high classification power between the HNC patients and healthy controls. Moreover, using Capnocytophaga in conjunction with symptom of voice/speech difficulty achieved an overall predicting accuracy of 92.5% comparing with using Capnocytophaga alone (79.2% accuracy) in distinguishing the HNC patients from healthy controls. Salivary microbial profiles and HNC symptoms may be potential biomarkers for HNC screening.

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Section: Discussionmentioning

confidence: 99%

Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

Zuo

Zhao

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Indeed, while GF mice show limited mucosal inflammation, visceral hypersensitivity due to altered pain processing in the brain is evident, which can be normalized by FMT with feces from conventional mice [ 143 , 144 , 145 ]. Gut microbe components, such as certain TLR ligands, formyl peptide receptor 1 agonists, and SCFAs, can directly enhance visceral pain sensitivity by stimulating primary nociceptive neurons in dorsal root ganglia (DRG) or indirectly by activating inflammatory immune response in the gut [ 146 , 147 ]. On the other hand, microbe-mediated kynurenic acid, serine proteases, and bile acids directly reduce pain by inactivating DRG neurons or indirectly by releasing opioid-like factors from mucosal immune cells [ 146 ].…”

Section: Microbiota-mediated Serotonergic Signaling In Ibs Pathologymentioning

confidence: 99%

Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome

Mishima¹,

Ishihara²

2021

IJMS

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Irritable bowel syndrome (IBS) is a chronic functional disorder that affects the gastrointestinal tract. Details regarding the pathogenesis of IBS remain largely unknown, though the dysfunction of the brain-gut-microbiome (BGM) axis is a major etiological factor, in which neurotransmitters serve as a key communication tool between enteric microbiota and the brain. One of the most important neurotransmitters in the pathology of IBS is serotonin (5-HT), as it influences gastrointestinal motility, pain sensation, mucosal inflammation, immune responses, and brain activity, all of which shape IBS features. Genome-wide association studies discovered susceptible genes for IBS in serotonergic signaling pathways. In clinical practice, treatment strategies targeting 5-HT were effective for a certain portion of IBS cases. The synthesis of 5-HT in intestinal enterochromaffin cells and host serotonergic signaling is regulated by enteric resident microbiota. Dysbiosis can trigger IBS development, potentially through aberrant 5-HT signaling in the BGM axis; thus, the manipulation of the gut microbiota may be an alternative treatment strategy. However, precise information regarding the mechanisms underlying the microbiota-mediated intestinal serotonergic pathway related to the pathogenesis of IBS remains unclear. The present review summarizes current knowledge and recent progress in understanding microbiome–serotonin interaction in IBS cases.

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“…Based on these findings, it is conceivable that gut dysbiosis and the consequent alterations in gut permeability may participate to the occurrence of vaginal dysbiosis and to the development of chronic submucosa vulvar inflammation in VVS patients [10]. Furthermore, findings that bacterial-derived factors may directly activate sensory neurons by acting on nociceptors [41,42], suggest that the presence of specific bacteria in contact with visceral organs may evoke vulvar pain in VVS women.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Gut Microbiota in Patients With Vulvovestibular Syndrome

Coda

Cassis²,

Angioletti³

et al. 2021

J Clin Med Res

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Background: Vulvovestibular syndrome (VVS) or vulvodynia is a chronic, heterogeneous and multifactorial disease that dramatically affects women's health and quality of life. Despite important advancements in understanding VVS etiology have been achieved in the past decades, VVS still remains an elusive and complex condition without identifiable causes and effective treatments. In the present observational, retrospective, case-control study, we sought to investigate whether gut dysbiosis developed in patients with VVS. Methods: To this aim, we compared both bacterial and fungal composition in VVS patients (n = 74; 34.3 ± 10.9 years old) with those of women without gynecological symptoms (n = 13 healthy control; 38.3 ± 10.4 years old). Furthermore, to assess whether gut ecology may have an impact on gut function, the degree of intestinal inflammation (calprotectin levels) and gut permeability (zonulin levels) were also evaluated. Results: VVS patient developed gut dysbiosis, mainly characterized by a significant increase of Escherichia coli along with increased colonization of mold/yeast compared to healthy controls. Furthermore, fecal levels of zonulin indicated that in VVS patients gut dysbiosis translated into increased gut permeability. Conclusion: Our preliminary study, by demonstrating that alterations in gut microbiota and intestinal permeability are present in patients with VVS, highlights the novel notion that gut dysbiosis may be considered an important associated factor for VVS. These findings, if confirmed, may be clinically relevant and may help in choosing further diagnostic methods and more effective therapies for these patients.

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Painful interactions: Microbial compounds and visceral pain

Cited by 23 publications

References 213 publications

Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome

Evaluation of Gut Microbiota in Patients With Vulvovestibular Syndrome

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