Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

Zuo, Hao; Fu, Mei R.; Zhao, Hui; Du, Xin Wen; Hu, Zi Yi; Zhao, Xun; Ji, Xiao Qin; Feng, Xian; Zhumajiang, Wuerken; Zhou, Ting; Tian, Ya; Pei, Xiao; Yu, Rong; Hu, Xingyu

doi:10.3389/fcimb.2020.514943

Cited by 18 publications

(16 citation statements)

References 62 publications

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“…The samples were obtained from patients with HNSCC, of which OSCC was the most frequently studied tumor [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. The studies also included samples from the following: oropharyngeal squamous cell carcinoma (OPSCC) [ 21 , 43 ], gingival squamous cell carcinoma (GSCC) [ 44 ]; unspecified oral cavity cancer (OCC) (45); oropharyngeal cancers (OPC) [ 45 ]; nasopharyngeal carcinoma (NPC) [ 46 ]; unspecified HNSCCs [ 47 , 48 , 49 , 50 , 51 ]. In addition, certain oral potentially malignant disorders (OPMDs), such as oral leukoplakia, were also studied.…”

Section: Resultsmentioning

confidence: 99%

Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers

Metsäniitty

Hasnat

Salo

et al. 2021

Cancers

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Head and neck squamous cell carcinoma (HNSCC) comprises the majority of tumors in head and neck tissues. The prognosis of HNSCC has not significantly improved for decades, signifying the need for new diagnostic and therapeutic targets. Recent evidence suggests that oral microbiota is associated with carcinogenesis. Thus, we conducted a comprehensive systematic review to evaluate the current evidence regarding the role of oral microbiota in HNSCC and whether their targeting may confer diagnostic, prognostic or therapeutic utility. Following the screening of 233 publications retrieved from multiple databases, 34 eligible studies comprising 2469 patients were compiled and critically appraised. Importantly, many oral pathogens, such as Porphyromonas gingivalis and Fusobacterium nucleatum were linked to certain oral potentially malignant lesions and various types of HNSCC. Furthermore, we summarized the association between the expression profiles of different oral bacterial species and their tumorigenic and prognostic effects in cancer patients. We also discussed the current limitations of this newly emerging area and the potential microbiota-related strategies for preventing and treating HNSCC. Whilst many clinical studies are underway to unravel the role of oral microbiota in cancer, the limited available data and experimental approaches reflect the newness of this promising yet challenging field.

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Section: Resultsmentioning

confidence: 99%

Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers

Metsäniitty

Hasnat

Salo

et al. 2021

Cancers

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“…Fresh faeces samples are placed in insulating polystyrene foam containers on an ice bath, transported from the hospital to the laboratory and stored at −80°C. The samples are collected and transported using the adopted method 33…”

Section: Methods and Analysesmentioning

confidence: 99%

Relation of gut microbiota and postoperative gastrointestinal dysfunction in older patients with colon cancer undergoing elective colon resection: a protocol for a prospective, observational cohort study

Wang

Zuo

et al. 2022

BMJ Open

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IntroductionGut microbiota (GM) appears critical for gastrointestinal symptoms, but whether alterations in GM are associated with increased risk of postoperative gastrointestinal dysfunction (POGID) in older patients with colon cancer (CC) undergoing elective colon resection remains unclear.Methods and analysisThis study aims to prospectively recruit 284 elderly patients with CC undergoing elective colon resection. GM of fresh faeces specimens is characterised using 16S rRNA gene sequencing. Data are collected preoperatively, daily postoperatively during the in-hospital stay, and follow-up visits are scheduled four times within 30 days after discharge. Associations with POGID will be investigated using logistic regression models to calculate ORs with 95% CIs. The models include the adjustment for age, sex, frequency of spicy diet, coffee drinking and tea drinking, tobacco and alcohol history, diabetes, obesity, gastroenteritis, preoperative gut microbial composition. Furthermore, we will use joint modelling for longitudinal data to study several outcome variables simultaneously.Ethics and disseminationThis study was approved by the Institutional Review Board of West China Hospital, Sichuan University (IRB Number: 20201334). The results will be disseminated through peer-reviewed publications or conference presentations.Trial registration numberIt has been registered in PROSPERO, number CRD42019145032. It has been registered in the Chinese clinical trial registry, number ChiCTR2100043646.

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“…A 16S rRNA gene sequencing study on Caucasian participants found that a panel of Capnocytophaga, Corynebacterium, Porphyromonas, Haemophilus, Oribacterium, Rothia, and Paludibacter could discriminate between patients with oropharyngeal cancers and oral cavity cancers from age-matched controls (p<0.05) ( 114 ). A recent study demonstrated that an elevated presence of Capnocytophaga (AUC= 0.81 p<0.05) in saliva could be used as a probable screening tool for prognosis and diagnosis of HNC patients ( 115 ). Similarly, abundance of Dialister (p<0.05) in HNC patients correlated with aggressive laryngeal and oral tumors ( 116 ).…”

Section: Salivary Microbiomementioning

confidence: 99%

Saliva Based Liquid Biopsies in Head and Neck Cancer: How Far Are We From the Clinic?

Patel

et al. 2022

Front. Oncol.

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Head and neck cancer (HNC) remains to be a major cause of mortality worldwide because of confounding factors such as late-stage tumor diagnosis, loco-regional aggressiveness and distant metastasis. The current standardized diagnostic regime for HNC is tissue biopsy which fails to determine the thorough tumor dynamics. Therefore, due to the ease of collection, recent studies have focused on the utility of saliva based liquid biopsy approach for serial sampling, early diagnosis, prognosis, longitudinal monitoring of disease progression and treatment response in HNC patients. Saliva collection is convenient, non-invasive, and pain-free and offers repetitive sampling along with real time monitoring of the disease. Moreover, the detection, isolation and analysis of tumor-derived components such as Circulating Tumor Nucleic Acids (CTNAs), Extracellular Vesicles (EVs), Circulating Tumor Cells (CTCs) and metabolites from saliva can be used for genomic and proteomic examination of HNC patients. Although, these circulatory biomarkers have a wide range of applications in clinical settings, no validated data has yet been established for their usage in clinical practice for HNC. Improvements in isolation and detection technologies and next-generation sequencing analysis have resolved many technological hurdles, allowing a wide range of saliva based liquid biopsy application in clinical backgrounds. Thus, in this review, we discussed the rationality of saliva as plausible biofluid and clinical sample for diagnosis, prognosis and therapeutics of HNC. We have described the molecular components of saliva that could mirror the disease status, recent outcomes of salivaomics associated with HNC and current technologies which have the potential to improve the clinical value of saliva in HNC.

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Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

Cited by 18 publications

References 62 publications

Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers

Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers

Relation of gut microbiota and postoperative gastrointestinal dysfunction in older patients with colon cancer undergoing elective colon resection: a protocol for a prospective, observational cohort study

Saliva Based Liquid Biopsies in Head and Neck Cancer: How Far Are We From the Clinic?

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