Pain-related evoked potentials after intraepidermal electrical stimulation to Aδ and C fibers in patients with neuropathic pain

Omori, Shigeru; Isose, Sagiri; Misawa, Sonoko; Watanabe, Keisuke; Sekiguchi, Yukari; Shibuya, Kazumoto; Beppu, Minako; Amino, Hiroshi; Kuwabara, Satoshi

doi:10.1016/j.neures.2017.03.007

Cited by 29 publications

(28 citation statements)

References 44 publications

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“…In this study, the parameters for selective stimulation of Aδ fibers for recording EPs were based on the experimental protocol of our previous studies, which involves using trains of double pulses with an ISI of 10 ms at an intensity that was approximately twice the sensory threshold (Otsuru et al, 2010 ). The values of EP parameters recorded, such as the latency of N2 and P2, amplitudes of EPs (N2-P2), and sensory threshold, were within the range of the results of our and another group’s studies, which employed similar common parameters (Mouraux et al, 2010 , 2014 ; Omori et al, 2013 , 2017 ; Iwabe et al, 2014 ; Kodaira et al, 2014 ). EPs involving nociception are also substantially modulated by participant variables including vigilance, emotional state, alertness and especially, attention to the stimulus (in review, Legrain et al, 2012 ).…”

Section: Discussionsupporting

confidence: 86%

“…The peak latencies of N2 and P2 were approximately 200 and 350 ms, respectively. In addition, we considered the peak latencies of N2 and P2 to be the latency period during 180–250 and 300–400 ms, respectively (Inui et al, 2002 ; Mouraux et al, 2010 ; Otsuru et al, 2010 ; Iwabe et al, 2014 ; Kodaira et al, 2014 ; Omori et al, 2017 ). Amplitudes of EPs were normalized to those recorded before tSMS.…”

Section: Methodsmentioning

confidence: 99%

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Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing

Kirimoto

Tamaki

Otsuru

et al. 2018

Front. Hum. Neurosci.

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Transcranial static magnetic field stimulation (tSMS) is a novel and inexpensive, non-invasive brain stimulation (NIBS) technique. Here, we performed non-invasive modulation of intra-epidermal electrical stimulation-evoked potentials (IES-EPs) by applying tSMS or sham stimulation over the primary motor (M1) and somatosensory (S1) cortices in 18 healthy volunteers for 15 min. We recorded EPs after IES before, right after, and 10 min after tSMS. The IES-EP amplitude was significantly reduced immediately after tSMS over M1, whereas tSMS over S1 and sham stimulation did not affect the IES-EP amplitude. Thus, tSMS may affect cortical nociceptive processing. Although the results of intervention for experimental acute pain in healthy subjects cannot be directly translated into the clinical situation, tSMS may be a potentially useful NIBS method for managing chronic pain, in addition to standard of care treatments.

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Section: Discussionsupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing

Kirimoto

Tamaki

Otsuru

et al. 2018

Front. Hum. Neurosci.

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“…Intraepidermal electrical stimulation has also been described as a potential additional tool in detecting functional changes in Aδ‐fibers and C‐fibers in SFN, and in patients with neuropathic pain …”

Section: Epidemiologymentioning

confidence: 99%

“…,108 and in patients with neuropathic pain 109. 2.6 | Imaging 2.6.1 | Peripheral nerve ultrasound Ultrasound (US) showed enlargement in cross-sectional area of the sural nerve in SFN patients with reduced IENFD, compared with body mass index matched healthy controls,110 indicating changes in structure or morphology of larger nerve fibers in SFN.…”

mentioning

confidence: 99%

Small‐fiber neuropathy: Expanding the clinical pain universe

Sopacua

Hoeijmakers

Merkies

et al. 2019

J Peripheral Nervous Sys

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Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to a significant reduction in quality of life. According to international criteria, the diagnosis is established by the assessment of intraepidermal nerve fiber density and/or quantitative sensory testing. SFN is mainly associated with autoimmune diseases, sodium channel gene variants, diabetes mellitus, and vitamin B12 deficiencies, although in more than one half of patients no etiology can be identified. Recently, gain‐of‐function variants in the genes encoding for the Nav1.7, Nav1.8 and Nav1.9 sodium channel subunits have been discovered in SFN patients, enlarging the spectrum of underlying conditions. Sodium channel gene variants associated with SFN can lead to a diversity of phenotypes, including different pain distributions and presence or absence of autonomic symptoms. This suggests that SFN is part of a clinical continuum. New assessments might contribute to a better understanding of the cellular and molecular substrates of SFN and might provide improved diagnostic methods and trial designs in the future. Identification of the underlying mechanisms may inform the development of drugs that more effectively address neuropathic pain and autonomic symptoms of SFN.

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“…EEG recordings are particularly important in the diagnosis of epilepsy [3] and in brain computer interface (BCI) [4]. Several studies have shown that using EEG analysis can reveal pain responses from various stimulations such as heat or cold [5][6][7], electrical ones [8,9] and laser [10,11]. Components of pain-event related potential (pain-ERP) were used as signals to estimate pain perception of healthy subjects [7,8].…”

Section: Introductionmentioning

confidence: 99%

Classification of Pain Event Related Potential for Evaluation of Pain Perception Induced by Electrical Stimulation

Tripanpitak

Viriyavit

Huang

et al. 2020

Sensors

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Variability in individual pain sensitivity is a major problem in pain assessment. There have been studies reported using pain-event related potential (pain-ERP) for evaluating pain perception. However, none of them has achieved high accuracy in estimating multiple pain perception levels. A major reason lies in the lack of investigation of feature extraction. The goal of this study is to assess four different pain perception levels through classification of pain-ERP, elicited by transcutaneous electrical stimulation on healthy subjects. Nonlinear methods: Higuchi's fractal dimension, Grassberger-Procaccia correlation dimension, with auto-correlation, and moving variance functions were introduced into the feature extraction. Fisher score was used to select the most discriminative channels and features. As a result, the correlation dimension with a moving variance without channel selection achieved the best accuracies of 100% for both the two-level and the three-level classification but degraded to 75% for the four-level classification. The best combined feature group is the variance-based one, which achieved accuracy of 87.5% and 100% for the four-level and three-level classification, respectively. Moreover, the features extracted from less than 20 trials could not achieve sensible accuracy, which makes it difficult for an instantaneous pain perception levels evaluation. These results show strong evidence on the possibility of objective pain assessment using nonlinear feature-based classification of pain-ERP.

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Pain-related evoked potentials after intraepidermal electrical stimulation to Aδ and C fibers in patients with neuropathic pain

Cited by 29 publications

References 44 publications

Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing

Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing

Small‐fiber neuropathy: Expanding the clinical pain universe

Classification of Pain Event Related Potential for Evaluation of Pain Perception Induced by Electrical Stimulation

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