2020
DOI: 10.1186/s12883-020-1604-z
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Pain reduction by inducing sensory-motor adaptation in Complex Regional Pain Syndrome (CRPS PRISMA): protocol for a double-blind randomized controlled trial

Abstract: Background: Complex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their perception of and attention to the affected body part and sensory information in the affected side of space. Prism Adaptation (PA) is a behavioural intervention targeted at reducing attention deficits in post-stroke hemispatial neglect. PA also appears to reduce pain and other CRPS symptoms; howe… Show more

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Cited by 15 publications
(32 citation statements)
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References 109 publications
(171 reference statements)
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“…Prism adaptation [212,213], adapted from rehabilitation of poststroke neglect, is hypothesised to normalise attention bias and/or the sensory-motor integration system in CRPS. In small uncontrolled studies, it has been shown to reduce subjective body midline bias, body representation distortions, and pain and improve autonomic symptoms and motor function in CRPS [55,69,214] (see [215] for a protocol for a randomised controlled trial). Neurorehabilitation has certain advantages over analgesic medications and brain stimulation.…”
mentioning
confidence: 99%
“…Prism adaptation [212,213], adapted from rehabilitation of poststroke neglect, is hypothesised to normalise attention bias and/or the sensory-motor integration system in CRPS. In small uncontrolled studies, it has been shown to reduce subjective body midline bias, body representation distortions, and pain and improve autonomic symptoms and motor function in CRPS [55,69,214] (see [215] for a protocol for a randomised controlled trial). Neurorehabilitation has certain advantages over analgesic medications and brain stimulation.…”
mentioning
confidence: 99%
“…It was prospectively registered (ISRCTN46828292 42 ), and the full details of the study are reported in the study protocol and analysis plan. 34 Any protocol deviations are specified in the relevant sections of the article. Anonymised participant-level data generated during the current trial ( https://osf.io/ba6fq/ ), digital study materials (training protocol and video, PsychoPy experiment files, and stimuli; https://osf.io/7fk2v/ ), and analysis scripts ( https://osf.io/w67rx/ ) are publicly available in an Open Science Framework repository.…”
Section: Methodsmentioning
confidence: 99%
“…Participants randomised to the PA treatment used welding goggles fitted with 35-diopter Fresnel lenses that induced approximately 19° lateral optical deviation (visual shift) away from the CRPS-affected side. In each treatment session, participants were seated approximately 50 cm from a wall or other vertical surface (the actual distance was adjusted individually to correspond to the participant's almost fully extended arm, and thus, it differs from the 60-cm distance anticipated in the trial protocol 34 ). An A4 sheet was positioned on the wall in a landscape orientation at the eye level and in line with their body midline.…”
Section: Methodsmentioning
confidence: 99%
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“…However, its potential role in addressing spatial biases in CRPS has more recently become a topic of investigation and has led to studies of its efficacy as a treatment approach [77][78][79][80]. Whilst these have demonstrated positive effects, they have been limited by small sample sizes and design restrictions [81]. It is therefore hoped that further research will improve our understanding of the known neurophysiological changes that occur in CRPS and of the potential of Prism Adaptation as a novel method of pain relief and symptom improvement.…”
Section: Other and Emerging Therapiesmentioning
confidence: 99%