2020
DOI: 10.1155/2020/4561831
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Neuropsychological Changes in Complex Regional Pain Syndrome (CRPS)

Abstract: Complex Regional Pain Syndrome (CRPS) is a poorly understood chronic pain condition of multifactorial origin. CRPS involves sensory, motor, and autonomic symptoms primarily affecting one extremity. Patients can also present with neuropsychological changes such as reduced attention to the CRPS-affected extremity, reminiscent of hemispatial neglect, yet in the absence of any brain lesions. However, this “neglect-like” framework is not sufficient to characterise the range of higher cognitive functions that can be… Show more

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Cited by 60 publications
(60 citation statements)
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References 222 publications
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“…Altogether, the puzzle of symptoms and neural information patters characterizing this enigmatic condition seems to point to a difficulty with the body mental representation (Kuttikat et al, 2016;Halicka et al, 2020), rather than a mere deficit in peripheral transmission (Yvon et al, 2018) Tables Table 1. Summary of all preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in…”
Section: Resultsmentioning
confidence: 99%
“…Altogether, the puzzle of symptoms and neural information patters characterizing this enigmatic condition seems to point to a difficulty with the body mental representation (Kuttikat et al, 2016;Halicka et al, 2020), rather than a mere deficit in peripheral transmission (Yvon et al, 2018) Tables Table 1. Summary of all preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in…”
Section: Resultsmentioning
confidence: 99%
“…Research has also begun to explore neurophysiological approaches. Evidence from a number of studies suggests a structural reorganisation of the brain is associated with chronic pain [70,71]. Such reorganisation has been recognised in CRPS and its association with pain experience is supported by studies of how CRPS patients represent and attend to their affected limb [72,73] and of the consequent impacts of visual neglect and emotional changes about the painful limb on motor and autonomic function [74][75][76].…”
Section: Other and Emerging Therapiesmentioning
confidence: 97%
“…The use of mediated virtual reality with patients with recalcitrant CRPS is promising, with a recent study finding therapeutic effect from a single exposure to a digitally manipulated image of the affected limb, both in terms of pain and body perception disturbance [90]. Use of the rubber hand illusion [91] has progressed our understanding of body dis-ownership in CRPS [92] and has similarly been proposed as a potential means of working toward the toleration of touch on a CRPS-affected limb [71].…”
Section: Other and Emerging Therapiesmentioning
confidence: 99%
“…Given the above evidence, it is important that further review-based research is undertaken and brings together understanding on the factors which influence PSP. It is also important that such research documents qualitative evidence and insight to lived experiences [ 14 ]. An integrative or mixed studies review may be best placed to achieve this.…”
Section: Introductionmentioning
confidence: 99%