Pain modulation induced by respiration: Phase and frequency effects

Arsenault, Marianne; Ladouceur, Alexandra; Lehmann, Alexandre; Rainville, Pierre; Piché, Mathieu

doi:10.1016/j.neuroscience.2013.07.048

Cited by 34 publications

(31 citation statements)

References 48 publications

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“…Furthermore, pain-related brain activity was found to be reduced only during the fast inspiration period, as compared to other patterns of breathing. However, this decreased pain-related activity was dissociated from spinal nociceptive transmission 38. Taken together, our results suggest that central mechanisms play an important role in neuropathic pain in SCI patients.…”

Section: Discussionmentioning

confidence: 50%

A novel nonpharmacological intervention – breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury – a preliminary study

Li¹,

Davis²,

Frontera³

et al. 2016

JPR

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ObjectiveThe objective of this study was to examine the effectiveness of a novel nonpharmacological intervention – breathing-controlled electrical stimulation (BreEStim) – for neuropathic pain management in spinal cord injury (SCI) patients.Subjects and methodsThere were two experiments: 1) to compare the effectiveness between BreEStim and conventional electrical stimulation (EStim) in Experiment (Exp) 1 and 2) to examine the dose–response effect of BreEStim in Exp 2. In Exp 1, 13 SCI subjects (6 males and 7 females, history of SCI: 58.2 months, from 7 to 150 months, impairments ranging from C4 AIS B to L1 AIS B) received both BreEStim and EStim in a randomized order with at least 3 days apart. A total of 120 electrical stimuli to the median nerve transcutaneously were triggered by voluntary inhalation during BreEStim or were randomly delivered during EStim. In Exp 2, a subset of 7 subjects received BreEStim120 and 240 stimuli randomly on two different days with 7 days apart (BreEStim120 vs BreEStim240). The primary outcome variable was the visual analog scale (VAS) score.ResultsIn Exp 1, both BreEStim and EStim showed significant analgesic effects. Reduction in VAS score was significantly greater after BreEStim (2.6±0.3) than after EStim (0.8±0.3) (P<0.001). The duration of analgesic effect was significantly longer after BreEStim (14.2±6 hours) than after EStim (1.9±1 hours) (P=0.04). In Exp 2, BreEStim120 and BreEStim240 had similar degree and duration of analgesic effects.ConclusionThe findings from this preliminary study suggest that BreEStim is an effective alternative nonpharmacological treatment for chronic neuropathic pain in patients suffering from SCI.

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Section: Discussionmentioning

confidence: 50%

A novel nonpharmacological intervention – breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury – a preliminary study

Li¹,

Davis²,

Frontera³

et al. 2016

JPR

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“…A second key prediction is that respiration-locked modulation of cortical gamma activity and phase transition timing directly links respiratory behavior to higher cortical processes, including cognitive and limbic functions, sensory perception and motor control. The respiration-locked modulation of neocortical activity we propose here would thus provide a neuronal mechanism and causal link between respiration and pain perception (Arsenault et al, 2013; Iwabe et al, 2014), motor control (Ebert et al, 2002; Rassler and Raabe, 2003; Li and Laskin, 2006; Iwamoto et al, 2010; Cao et al, 2012; Krupnik et al, 2015), attention (Gallego et al, 1991; Krupnik et al, 2015) and emotion (Benson et al, 1974; Arch and Craske, 2006; Homma and Masaoka, 2008). …”

mentioning

confidence: 83%

“…Pain-studies in humans showed that pain perception is reduced during inspiration (Arsenault et al, 2013) and that focused slow breathing reduces the perceived severity of pain (Zautra et al, 2010). Other clinical studies have shown that the strength of cortico-spinal communication assessed with transcranial magnetic stimulation (TMS) is modulated in phase with respiration (Li and Rymer, 2011).…”

mentioning

confidence: 99%

Breathing as a Fundamental Rhythm of Brain Function

Heck

McAfee

Liu

et al. 2017

Front. Neural Circuits

177

184

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Ongoing fluctuations of neuronal activity have long been considered intrinsic noise that introduces unavoidable and unwanted variability into neuronal processing, which the brain eliminates by averaging across population activity (Georgopoulos et al., 1986; Lee et al., 1988; Shadlen and Newsome, 1994; Maynard et al., 1999). It is now understood, that the seemingly random fluctuations of cortical activity form highly structured patterns, including oscillations at various frequencies, that modulate evoked neuronal responses (Arieli et al., 1996; Poulet and Petersen, 2008; He, 2013) and affect sensory perception (Linkenkaer-Hansen et al., 2004; Boly et al., 2007; Sadaghiani et al., 2009; Vinnik et al., 2012; Palva et al., 2013). Ongoing cortical activity is driven by proprioceptive and interoceptive inputs. In addition, it is partially intrinsically generated in which case it may be related to mental processes (Fox and Raichle, 2007; Deco et al., 2011). Here we argue that respiration, via multiple sensory pathways, contributes a rhythmic component to the ongoing cortical activity. We suggest that this rhythmic activity modulates the temporal organization of cortical neurodynamics, thereby linking higher cortical functions to the process of breathing.

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“…Além disso, a análise do domínio do tempo mostrou valores significativamente mais elevados para o índice RMSSD após a mASR nas gestantes, o que indica maior modulação vagal após a manobra. Este aumento da modulação parassimpática concorda com a hipótese do estudo e pode ser um indicativo clínico de relaxamento, uma vez que a manobra estimula o aumento do volume corrente, o que diminui a modulação simpática e produz sensação de bemestar e redução da dor [8,[19][20][21][22]. Miyazato et al [19] mostraram que a redução de índices da modulação parassimpática estão relacionadas à sensação de…”

Section: Discussionunclassified

Respiração lenta e profunda aumenta a modulação vagal em gestantes

Farche

Jürgensen

Rossi

et al. 2017

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. RESUMOOBJETIVOS: Comparar a resposta da modulação autonômica da frequência cardíaca de gestantes e mulheres não gestantes, antes e após a manobra de acentuação da arritmia sinusal respiratória. MÉTODOS: Foi realizado um estudo transversal com amostra de 24 mulheres, divididas em dois grupos: grupo gestantes (independente da idade gestacional) e grupo controle (não gestantes). A avaliação consistiu em registro dos intervalos RR por um cardiofrequencímetro, para análise de índices lineares e não lineares da variabilidade da frequência cardíaca. As avaliações foram feitas no repouso em decúbito lateral esquerdo, antes e após a manobra de acentuação da arritmia sinusal respiratória, que consiste em respirações lentas de cinco a seis ciclos por minuto. A razão expiração/inspiração e a diferença entre a inspiração e a expiração foram avaliadas durante a manobra. Foram comparados os resultados obtidos entre os dois grupos (gestantes e não gestantes), assim como os obtidos em cada grupo, antes e após a manobra. Para a análise estatística o nível de significância considerado foi p<0,05. RESULTADOS: Os índices lineares mostraram valores iniciais da modulação simpática (banda de baixa frequência) aumentados nas gestantes quando comparadas às mulheres não gestantes (gestantes: 68,9±28,1; controles: 49,3±11,7; p=0,002). Após a manobra respiratória, o índice obtido pela raiz quadrada da média do quadrado das diferenças entre os intervalos RR normais adjacentes aumentou no grupo gestantes (pré-manobra: 34,5±5,7; pós-manobra: 38,9±5,8; p=0,027), indicando aumento da atuação parassimpática para essa população após a aplicação da manobra. Além disso, houve aumento dos valores de complexidade, sugeridos pela entropia de Shanon após a manobra, para ambos os grupos, sendo o aumento maior nas gestantes. Em relação aos índices avaliados durante a manobra, ambos os grupos apresentaram valores da razão expiração/inspiração maiores que 1, o que sugere integridade do sistema nervoso autônomo. CONCLUSÕES: Houve melhora da regulação do sistema nervoso autônomo ao final da manobra respiratória para as gestantes, sugerindo que o padrão de respiração lenta e profunda possa aumentar a modulação vagal e conferir efeito cardioprotetor, além de ocasionar relaxamento e sensação de bem-estar.DESCRITORES: gravidez; respiração; sistema cardiovascular; frequência cardíaca; arritmia sinusal respiratória; sistema nervoso autônomo. ABSTRACTAIMS: To compare the responses of the heart rate autonomic modulation in pregnant and non-pregnant women before and after the respiratory sinus arrhythmia maneuver. METHODS: A cross-sectional study was conducted with a sample of 24 women, divided into two groups: pregnant group (independent of gestational age) and control group (non-pregnant). The evaluation consisted of recording the RR inter...

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Pain modulation induced by respiration: Phase and frequency effects

Cited by 34 publications

References 48 publications

A novel nonpharmacological intervention – breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury – a preliminary study

A novel nonpharmacological intervention – breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury – a preliminary study

Breathing as a Fundamental Rhythm of Brain Function

Respiração lenta e profunda aumenta a modulação vagal em gestantes

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Pain modulation induced by respiration: Phase and frequency effects

Cited by 34 publications

References 48 publications

A novel nonpharmacological intervention &ndash; breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury &ndash; a preliminary study

A novel nonpharmacological intervention &ndash; breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury &ndash; a preliminary study

Breathing as a Fundamental Rhythm of Brain Function

Respiração lenta e profunda aumenta a modulação vagal em gestantes

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A novel nonpharmacological intervention – breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury – a preliminary study

A novel nonpharmacological intervention – breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury – a preliminary study