Pain management during radiotherapy and radiochemotherapy in oropharyngeal cancer patients: single-institution experience

Konopka-Filippow, Monika; Zabrocka, Ewa; Wójtowicz, Aleksandra; Skalij, Piotr; Wojtukiewicz, Marek Z.; Sierko, Ewa

doi:10.1111/idj.12181

Cited by 17 publications

(11 citation statements)

References 34 publications

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“…The last analysed study is a retrospective single-institution experience written by Konopka-Filippow and colleagues. The primary endpoint of the study was the efficiency of the analgesic treatment in oropharyngeal cancer patients undergoing RT + CT. 36 In total, 42 patients were assessed: they were, therefore, treated with different analgesic protocols that made the different groups of subjects non-comparable. In 21 patients, strong opioids were used and only in 11 patients a TTS delivering buprenorphine or fentanyl was used.…”

Section: Methodsmentioning

confidence: 99%

The use of fentanyl in pain management in head and neck cancer patients: a narrative review

Giusti

Bossi

Mazzotta

et al. 2017

British Journal of Pain

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Fentanyl transdermal therapeutic system (TTS) seems to be an important option, thanks to the way of administration, the good safety and tolerability profiles to control baseline pain. For breakthrough cancer pain (BTcP), several formulations of transmucosal fentanyl are available. All the formulations seem to be active and safety but we lack head-to-head studies of fentanyl versus other strong opioids, as well as with different formulation of fentanyl, particularly for BTcP where H&N cancer population is very poorly represented.

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Section: Methodsmentioning

confidence: 99%

The use of fentanyl in pain management in head and neck cancer patients: a narrative review

Giusti

Bossi

Mazzotta

et al. 2017

British Journal of Pain

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“…Also, dyclonine seems to exhibit a stronger and longer-lasting analgesic effect on oral mucositis than lidocaine [124]. Paracetamol, nonsteroidal anti-inflammatory drugs (NSAID) and opioids are currently the most frequently used drugs to achive systemic analgesia [124,125,126], but only limited data on the most beneficial analgesic therapy are available. Between these medicines, opioids play an essential role in pain relief in patients with oral mucositis [125,126].…”

Section: Management Of Oral Mucositismentioning

confidence: 99%

“…Paracetamol, nonsteroidal anti-inflammatory drugs (NSAID) and opioids are currently the most frequently used drugs to achive systemic analgesia [124,125,126], but only limited data on the most beneficial analgesic therapy are available. Between these medicines, opioids play an essential role in pain relief in patients with oral mucositis [125,126]. Morphine may be administered parenterally [125,126] or orally as mouthwashes alone [127,128] or oral morphine rinse combined with the oral intake of a morphine solution [129].…”

Section: Management Of Oral Mucositismentioning

confidence: 99%

“…Between these medicines, opioids play an essential role in pain relief in patients with oral mucositis [125,126]. Morphine may be administered parenterally [125,126] or orally as mouthwashes alone [127,128] or oral morphine rinse combined with the oral intake of a morphine solution [129]. Another option is transdermal fentanyl which has been shown as an effective, convenient and well-tolerated treatment for severe mucositis pain.…”

Section: Management Of Oral Mucositismentioning

confidence: 99%

See 1 more Smart Citation

Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis

Stempniewicz

Ceranowicz

Warzecha

2019

IJMS

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Chemotherapy and/or head and neck radiotherapy are frequently associated with oral mucositis. Oral pain, odynophagia and dysphagia, opioid use, weight loss, dehydration, systemic infection, hospitalization and introduction of a feeding tube should be mentioned as the main determinated effect of oral mucositis. Oral mucositis leads to a decreased quality of life and an increase in treatment costs. Moreover, oral mucositis is a life-threatening disease. In addition to its own direct life-threatening consequences, it can also lead to a reduced survival due to the discontinuation or dose reduction of anti-neoplasm therapy. There are numerous strategies for the prevention or treatment of oral mucositis; however, their effectiveness is limited and does not correspond to expectations. This review is focused on the ghrelin and obestatin as potentially useful candidates for the prevention and treatment of chemo- or/and radiotherapy-induced oral mucositis.

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“…Pain management can significantly improve patients’ quality of life [2]. Antineoplastic treatment, e.g., radiation therapy, may also cause transient pain, which has to be managed pharmacologically [3]. Radiation therapy (RT) per se, however, significantly contributes to pain alleviation in cancer patients in multiple clinical scenarios [4,5].…”

Section: Introductionmentioning

confidence: 99%

Personalized Radiation Therapy in Cancer Pain Management

Sierko

Hempel

Zuzda

et al. 2019

Cancers

Self Cite

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The majority of advanced cancer patients suffer from pain, which severely deteriorates their quality of life. Apart from analgesics, bisphosphonates, and invasive methods of analgesic treatment (e.g., intraspinal and epidural analgesics or neurolytic blockades), radiation therapy plays an important role in pain alleviation. It is delivered to a growing primary tumour, lymph nodes, or distant metastatic sites, producing pain of various intensity. Currently, different regiments of radiation therapy methods and techniques and various radiation dose fractionations are incorporated into the clinical practice. These include palliative radiation therapy, conventional external beam radiation therapy, as well as modern techniques of intensity modulated radiation therapy, volumetrically modulated arch therapy, stereotactic radiosurgery or stereotactic body radiation therapy, and brachytherapy or radionuclide treatment (e.g., radium-223, strontium-89 for multiple painful osseous metastases). The review describes the possibilities and effectiveness of individual patient-tailored conventional and innovative radiation therapy approaches aiming at pain relief in cancer patients.

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Pain management during radiotherapy and radiochemotherapy in oropharyngeal cancer patients: single-institution experience

Abstract: High incidence of pain during RT and RT-CT calls for increased awareness of the importance of pain monitoring and treatment during RT of OPC patients. The analgesic treatment had to be adjusted individually.

Cited by 17 publications

References 34 publications

The use of fentanyl in pain management in head and neck cancer patients: a narrative review

The use of fentanyl in pain management in head and neck cancer patients: a narrative review

Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis

Personalized Radiation Therapy in Cancer Pain Management

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