Pain-inducing laryngeal paragangliomas (non-chromaffin)

Ali, Syed N.; Aird, D. W.; Bihari, J.

doi:10.1017/s0022215100093968

Cited by 24 publications

(14 citation statements)

References 19 publications

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“…The clinical and pathological data for 127 of these [1, are listed in table 1. Although data for individual cases were not supplied in the recent report of 41 cases by Milroy et al [57], infor mation regarding 5 of their cases had appeared in earlier publica tions [4,7,13,28,47], Four cases [10, 11 ; 16, 17; 24, 25; 44, 45] had been published twice; at least eight of the tumors [4,5,7,12,[26][27][28]33] had been reported earlier as paragangliomas (table 2); and seven LAC (supplied by Dr. Alfio Ferlito and Dr. James Woodruff) appear in print for the first time in this article (tables 1,3). Additional data obtained by communication with the authors or culled from the literature has been provided for many of these cases.…”

Section: Methodsmentioning

confidence: 99%

Atypical Carcinoid Tumor of the Larynx

Woodruff

Senie

1991

ORL

101

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To better characterize the clinical and pathological features of the laryngeal atypical carcinoid (LAC), 127 of the published cases were analyzed. The LAC had a predilection for males (3 m:1 f), with a peak incidence in the 6th and 7th decades of life. Seventy-eight percent of patients with a relevant clinical history were smokers. Most tumors presented in the supraglottic larynx (96%) and the mean size of the measured primary lesions was 1.6 cm. The tumors were frequently argyrophil (97% of those so stained), rarely argentaffin (2 cases), and on immunohisto-chemistry were often reactive when stained for keratins (96%), chromogranin A (94%), and calcitonin (80%). Surgical resection was the principal modality of treatment. Of the 127 cases, metastasis to neck nodes were found in 43%, to skin or subcutaneous sites in 22%, and to distant sites in 44%. Of the 119 patients with follow-up, 49% died with tumor. The cumulative proportion surviving was 48% at 5 years and 30% at 10 years, and there were significantly worse survival rates among patients with tumors larger than 1 cm, and for patients developing tumor involvement of skin and subcutaneous tissues. Adjuvant radiation did not affect survival rates.

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Section: Methodsmentioning

confidence: 99%

Atypical Carcinoid Tumor of the Larynx

Woodruff

Senie

1991

ORL

101

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“…Subsequently, a considerable number of such cases have been reported as carcinoids, atypical carcinoids, malignant carcinoids, and neuroendocrine carcinomas (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In some of these earlier discussions, the cytologic and clinical features of the tumors were overtly malignant, yet the term carcinoid tumor was applied without further modification, emphasizing the nomenclature problem discussed above.…”

Section: Neuroendocrine Carcinomas and Related Neoplasms (Group 1)mentioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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Tumors exhibiting neuroectodermal differentiation occur throughout the body, and the diverse tissues of the head and neck give rise to a wide assortment of these neoplasms. Neuroectodermal neoplasms may be divided into lesions showing primarily epithelial differentiation (Group I, neuroendocrine carcinomas) and a more diverse group (Group II) of nonepithelial neoplasms. This article reviews these neuroectodermal tumors of the head and neck with emphasis on the neuroendocrine carcinomas and their nomenclature. The author believes that with regard to Group I tumors, the older terminology of carcinoid, atypical carcinoid, and small cell carcinoma should be replaced by subclassifications of well-differentiated, moderately differentiated, and poorly differentiated neuroendocrine carcinoma. The latter category should be further subdivided into small cell and large cell variants. Neuroendocrine carcinomas, particularly the moderately differentiated subtype, are often underdiagnosed in the head and neck region. In the larynx, these tumors are the most common form of nonsquamous carcinoma. Poorly differentiated neuroendocrine carcinoma of small cell type is most common in the salivary glands but can occur elsewhere in the region. The large cell subtype of poorly differentiated neuroendocrine carcinoma has not been well documented in this region. However, the most likely candidate for this tumor category is the so-called sinonasal undifferentiated carcinoma. Group II tumors discussed include olfactory neuroblastoma, malignant melanoma, and Ewing's sarcoma. In addition, differential diagnostic problems related to Group I and II tumors are reviewed in detail. This article reviews and updates our understanding of neuroectodermal neoplasms arising in the head and neck. The focus is on tumors that exclusively involve this region or show a strong predilection to occur here.

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“…The presented patient's external auditory canal tumour was postulated to have arisen from paraganglionic tissue associated with Arnold's nerve. 6 These tumours are exquisitely painful and characteristically inconspicuous, eluding diagnosis. [2][3][4] Neither of these cases presented with pain, in contrast to our patient.…”

Section: Discussionmentioning

confidence: 99%