Pain during injection of propofol

This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia. In a randomized, double-blind trial, 90 women were allocated to receive one of three treatments prior to induction of anaesthesia with propofol. Patients in Group C received 2 ml normal saline, Group L, 2 ml, lidocaine 2% (40 mg) and Group T, 2 ml thiopentone 2.5% (50 mg). Venous discomfort was assessed with a visual analogue scale (VAS) 5-15 sec after commencing propofol administration using an infusion pump (rate 1000 micrograms.kg-1.min-1). Loss of consciousness occurred in 60-90 sec. Visual analogue scores (mean +/- SD) during induction were lower in Groups L (3.3 +/- 2.5) and T (4.1 +/- 2.7) than in Group C (5.6 +/- 2.3); P = 0.0031. The incidence of venous discomfort was lower in Group L (76.6%; P < 0.05) than in Group C (100%) but not different from Group T (90%). The VAS scores for recall of pain in the recovery room were correlated with the VAS scores during induction (r = 0.7045; P < 0.0001). Recovery room discharge times were similar: C (75.9 +/- 19.4 min); L 73.6 +/- 21.6 min); T (77.1 +/- 18.9 min). Assessing their overall satisfaction, 89.7% would choose propofol anaesthesia again. We conclude that lidocaine reduces the incidence and severity of propofol injection pain in ambulatory patients whereas thiopentone only reduces its severity.

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Epidural anesthesia with lidocaine reduces propofol injection pain

Yoshikawa

Wajima

Inoue

et al. 2001

Can J Anesth/J Can Anesth

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Purpose: To determine whether epidural lidocaine reduces the severity of propofol injection pain compared with iv lidocaine.Methods: A prospective, randomized double-blind clinical study was conducted in 120 female patients scheduled for elective gynecological laparotomy. A lumbar epidural catheter and an iv catheter placed in the cephalic vein of the non-dominant hand were used in all patients. Patients of the control group (Group C) were given epidural normal saline followed by iv normal saline then iv propofol. Patients of Group E were given epidural 2% lidocaine (0.08 mL·cm -1 ) followed by iv normal saline and then propofol. Patients of Group V were given epidural normal saline followed by iv 2% lidocaine (0.05 mL·kg -1 ) then propofol. Pain was scored as no pain=0, minimal pain=1, moderate pain=2, severe pain=3.Results: The pain scores, in group E; 1 (0-2) and group V; 2 (0-2), were significantly lower than in group C; 2 (1-3); median (25 th -75 th percentile) (P <0.001). There was no difference in pain score between groups E and V. The plasma lidocaine concentration 15 min after epidural lidocaine was 2.74 ± 0.54 µg·mL -1 , compared with 1.54 ± 0.31 µg·mL -1 at three minutes after iv lidocaine.Conclusion: Epidural and iv lidocaine equally reduced the severity of propofol injection pain despite higher lidocaine plasma concentrations in epidurally administered lidocaine. Objectif : Déterminer si la lidocaïne, en injection péridurale comparée à l'injection iv, peut réduire la douleur causée par l'administration de propofol.

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Pain during injection of propofol

Cited by 43 publications

References 13 publications

Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults

Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults

Thiopentone pretreatment for propofol injection pain in ambulatory patients

Epidural anesthesia with lidocaine reduces propofol injection pain

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