Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults

Euasobhon, Pramote; Dejarkom, Sukanya; Siriussawakul, Arunotai; Muangman, Saipin; Sriraj, Wimonrat; Pattanittum, Porjai; Lumbiganon, Pisake

doi:10.1002/14651858.cd007874.pub2

Cited by 61 publications

(57 citation statements)

References 126 publications

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“…A total of 8 studies [11,13,14,16,17–25] mentioned the side effects occurred during the anesthesia. The reported side effects in literatures were sporadic and diverse, thus we tried to describe the details of them (Table 2).…”

Section: The Side Effectsmentioning

confidence: 99%

“…However, in contrast of the proved efficacy of using lidocaine and other pharmacological interventions in published systematic reviews about adult patients, [11–13] the relevant systematic review about the efficacy and safety in reducing injection pain of propofol between lidocaine and other medications in pediatric patients has not been established.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients

et al. 2017

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Background:Propofol injection pain was considered as one conundrum during clinical anesthesia. The systematic review about the effect of lidocaine in reducing injection pain among children has not been established. The aim of the study was to systematically evaluate the efficacy and safety of such intervention.Methods:The literature search was performed from the inception to the May 31, 2016 in PubMed, Ovid EMBASE, and Cochrane database. All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled. The primary outcome included the incidence of injection pain and the incidence of propofol injection pain in different degrees. The data were combined to calculate the relative ratio and relevant 95% confidence interval. A meta-analysis was performed following the guidelines of the Cochrane Reviewer's Handbook and the PRISMA statement.Results:Data from the included 11 studies indicated that the incidence of injection pain was lower in lidocaine group than the incidence in saline control group and in propofol lipuro (medium- and long-chain triglycerides) group (pain occurrence: 22.1% in lidocaine vs 66.8% in saline, RR with 95% 0.34 [0.26, 0.43], I2 = 38%; 30.5% in lidocaine vs 46.9% in propofol lipuro, RR with 95% 0.68 [0.46, 1.00], I2 = 9%). There was no difference between lidocaine and ketamine/alfentanil both in reducing pain occurrence and in reducing pain severity (pain occurrence: 29.7% in lidocaine vs 25.8% in ketamine, RR with 95% 1.47 [0.16, 13.43], I2 = 94%; 31.0% in lidocaine vs 30.7% in alfentanil, RR with 95% 1.01 [0.69, 1.46], I2 = 11%). And the reported side effects revealed that the safety of lidocaine in pediatric patients was acceptable.Conclusion:Compared with ketamine and alfentanil, lidocaine would be served as one more effective treatment in consideration of its well-matched efficacy, acceptable accessibility, and reasonable safety. However, more high-quality evidences in pediatric patients are necessary.

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Section: The Side Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients

et al. 2017

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“…However, its administration is linked with the sensation of significant amount of pain. 11,12,13 This pain is caused due to the interaction of the aqueous phase of the emulsion and the free nerve endings. It might also be caused due to bradykinin production and the activated kinin cascade system.…”

Section: Discussionmentioning

confidence: 99%

Pain during intravenous Propofol injection and its prevention in the pediatric population. A randomized controlled trial.

Raza¹,

Siddiqui²,

Soomro³

et al. 2020

TPMJ

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Objectives: The aim of our study is to observe the pain difference as experienced by the pediatric patient when administered different preparations of propofol utilizing the verbal rating scale. Study Design: Prospective double-blind randomized control trial. Setting: A large tertiary care hospital in Karachi, Pakistan. Period: 6 months from June 2016 to November 2016. Material & Methods: The final patient population included in the study was n= 180 and were divided into six groups. These patients received general anesthesia and underwent surgery. Patients in Group A received 2ml of normal saline and a mixture of propofol and normal saline after waiting for half a minute. Group B patients received 0.5mg/kg Lidocaine followed by normal saline after waiting for half a minute. Group C received 2ml of normal saline followed by a mixture of propofol and Lidocaine after half a minute. Group D received 0.2mg/kg of Ketamine followed by a mixture of normal saline and propofol. Group E patients received 2ml of normal saline followed by a mixture of propofol and Ketamine half a minute later. And finally, patients belonging to group F received 2ml of normal saline followed by a mixture of propofol M/LCT and normal saline half a minute later respectively. Results: The gender, age, body weight and ASA grade of all the pediatric patients were similar having a P value of >0.05. The incidence rate of propofol injection pain in the groups were found to be Group A= 76.66%, Group B= 66.66%, Group C= 50%, Group D= 60%, Group E= 63.33%, Group F= 60% respectively. The incidence rate for adverse events was significantly lower in all the groups as compared to Group A that is the normal saline and propofol group having a p-value of less than 0.01. And the incidence rate of adverse events was lower in Groups C, D, E, and F were significantly lower than Group B having a p-value of less than 0.05. All the experimental groups had significantly lower scores of the VRS scale as compared to the control group (Group A) and the intergroup differences were found to be statistically significant having a p-value of less than 0.01. Conclusion: In our study, we found that the injection pain of propofol administration in the pediatric population was significantly reduced when using M/LCT pre-injection, 0.5mg/kg lidocaine or 0.2mg/kg of Ketamine. Another good combination is mixing 180mg propofol with 40mg of lidocaine or mixing propofol with 16mg of Ketamine.

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“…The exact mechanism of pain due to IV propofol is unknown. Different physical and pharmacological strategies have been assessed as means to reduce propofol-associated pain, but the best means has yet to be determined [2][3][4]. Propofol-induced pain on administration may prevent the use of propofol anesthesia in pediatric patients [5].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Intravenous Paracetamol in Combination with Lidocaine Pretreatment for Reducing Pain During Injection of Propofol

Hayat

Afshan

Nasir

et al. 2020

Cureus

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Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults

Cited by 61 publications

References 126 publications

Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients

Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients

Pain during intravenous Propofol injection and its prevention in the pediatric population. A randomized controlled trial.

Efficacy of Intravenous Paracetamol in Combination with Lidocaine Pretreatment for Reducing Pain During Injection of Propofol

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