Pain characterization in patients with Parkinson’s disease

OBJECTIVES:To assess the effect of withdrawal of the antiparkinsonian drug regimen administration on patients with PD and its relation to pain. METHODS:The sample included 22 men and 12 women who were candidates for neurosurgery to control motor signs and symptoms treated with L-dopa as a drug, alone or in combination with others (Cholinergic Antagonists; Dopamine Agents). All of them were examined at two different moments, with and without medication, and analyzed for painful symptoms. The Hoehn and Yahr scale was used for functional staging of the disease. Pain intensity was assessed by using the numerical verbal scale. RESULTS:The mean pain intensity among those on medication {2.17±0.39 (SE)} was significantly lower than in the abstinence group {4.2±0.59 (SE), p=0.006, Wilcoxon}, which corresponded to the increase in the total functional staging score from 93 to 111, respectively. CONCLUSION:The interruption of the administration of specific medications in patients with Parkinson's disease caused, or increased the intensity of, painful discomfort correlated with the intensity of functional impairment. This effect was also observed in women, but it was statistically relevant only for men. The results suggest that pain may be a "red flag" that points to the need for a therapeutic drug review when its presence or worsening is detected.

show abstract

“…In a published series assessing pain and PD, pain intensity was described as moderate and severe in 84% of the cases 12,13 .…”

Section: Discussionmentioning

confidence: 99%

Effect of medication withdrawal on pain in Parkinson’s disease patients – an observational study based on a sample of patients without antiparkinsonian medications

Lopes

Júnior

Porto

et al. 2021

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…These results are in line with other studies that show that non--motor symptoms can precede motor alterations and the diagnosis of PD, characterizing the prodromal phase of the disease 27 . Pain is commonly reported by individuals with PD and efforts have been made to investigate this symptom, however, there are few studies evaluating this symptom in the Brazilian population and there are no reports regarding LBP 28,29 . Despite the present study's limitations, as not having results on the type of pain and the specific clinical parameters of LBP, the present findings indicated the necessity for a routine evaluation of LBP in individuals with PD, in order to allow for a therapeutic assistance that is adequate to the demands of this population.…”

Section: Discussionmentioning

confidence: 99%

Should we retire statistical significance?

Correia¹,

Bagano²,

Melo³

2020

Brazilian Journal of Pain

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVES: Low back pain is a non-motor symptom commonly reported by individuals with Parkinson's disease. The aim of this study was to identify the prevalence of low back pain and its characteristics in individuals with Parkinson disease from a specialized treatment center. METHODS: Individuals with idiopathic Parkinson's disease answered a questionnaire for the assessment of clinical parameters and associated pain symptoms. Pain intensity was assessed using the visual analog scale. RESULTS: One hundred and twenty-three patients with mean age 68.1±11.8 years, and disease duration of 7.0±4.9 years, answered the questionnaire. Pain was reported by 102 (82.9%) patients: 71 (57.7%) had low back pain and 31 (25.2%) had pain in other body segments. There was no difference in age, education, time of Parkinson's disease symptoms and diagnosis when comparing individuals with and without pain, as well as individuals with pain in other segments and low back pain. The group with low back pain had pain in a greater number of body segments in addition to the lumbar region, with longer duration of this symptom and more frequent use of analgesic drugs. In the low back pain group, women had greater pain intensity.

show abstract

“…Entre las herramientas diagnósticas para la evaluación del dolor en la EP, las más utilizadas son: Brief Pain Inventory (36,38,(51)(52)(53)(54)(55)(56) y el SF 36 (49,57). También es de gran utilidad el cuestionario de dolor de McGil (38,(58)(59)(60). De manera más específica, el dolor de la EP puede valorarse a través del Estudio DoPaMiP (Douleur et maladie de Parkinson en Midi-Pyrénées), que sugiere que se puede hacer distinción inicial entre el dolor relacionado con la EP (PRPD) y el dolor no relacionado con la EP (PUPD) (38).…”

Section: Valoración Y Diagnóstico De Dolor En El Paciente Con Epunclassified

Dolor en la enfermedad de Parkinson. Una mirada a un aspecto poco conocido de esta patología

Rotondo

Toro

Bolívar

et al. 2019

Rev. Soc. Esp. Dolor.

View full text Add to dashboard Cite

Parkinson's disease (PD) is a neurodegenerative disease, the second most prevalent, after Alzheimer's disease. It presents both motor and non-motor symptoms; These include autonomic dysfunction, unexplained pain, cognitive impairment, anxiety, depression, among others. Some of these patients experience pain as an early symptom of Parkinson's, even before the expression of their disease. Among people who have PD and who experience pain, they describe it as a worrisome symptom, being a cause of suffering and disability. However, despite this, pain in PD often remains undiagnosed and untreated. Therefore, it is important to understand that pain can be part of the Parkinson's experience and learn ways to manage it.This paper reviews current data on possible mechanisms, classifi cations, evolution, potential risk factors and pain control in PD. The mechanism of pain in this situation is complex, and is infl uenced by different factors, which may be linked to pathological changes in the anatomical structures involved in nociceptive mechanisms.

show abstract

Pain characterization in patients with Parkinson’s disease

Cited by 8 publications

References 29 publications

Effect of medication withdrawal on pain in Parkinson’s disease patients – an observational study based on a sample of patients without antiparkinsonian medications

Effect of medication withdrawal on pain in Parkinson’s disease patients – an observational study based on a sample of patients without antiparkinsonian medications

Should we retire statistical significance?

Dolor en la enfermedad de Parkinson. Una mirada a un aspecto poco conocido de esta patología

Contact Info

Product

Resources

About