epigenética en el tratamiento del dolor / Epigenetics in the treatment of pain. Rev. Soc. Esp. Dolor. 2017. doi: 10.20986/resed.2017.3620/2017 Este es un archivo PDF de un manuscrito inédito que ha sido aceptado para su publicación en la Revista de la Sociedad Española del Dolor. Como un servicio a nuestros clientes estamos proporcionando esta primera versión del manuscrito en estado de prepublicación. El manuscrito será sometido a la corrección de estilo final, composición y revisión de la prueba resultante antes de que se publique en su forma final. Tenga en cuenta que durante el proceso de producción se pueden dar errores lo que podría afectar el contenido final. El copyright y todos los derechos legales que se aplican al artículo pertenecen a la Revista de la Sociedad Española de Dolor.
LA EPIGENÉTICA EN EL TRATAMIENTO DEL
Parkinson's disease (PD) is a neurodegenerative disease, the second most prevalent, after Alzheimer's disease. It presents both motor and non-motor symptoms; These include autonomic dysfunction, unexplained pain, cognitive impairment, anxiety, depression, among others. Some of these patients experience pain as an early symptom of Parkinson's, even before the expression of their disease. Among people who have PD and who experience pain, they describe it as a worrisome symptom, being a cause of suffering and disability. However, despite this, pain in PD often remains undiagnosed and untreated. Therefore, it is important to understand that pain can be part of the Parkinson's experience and learn ways to manage it.This paper reviews current data on possible mechanisms, classifi cations, evolution, potential risk factors and pain control in PD. The mechanism of pain in this situation is complex, and is infl uenced by different factors, which may be linked to pathological changes in the anatomical structures involved in nociceptive mechanisms.
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