Paget's disease of the scrotum: a case exhibiting positive prostate-specific antigen staining and associated prostatic adenocarcinoma

McLaren, K M; Aldridge, R. D.

doi:10.1046/j.1365-2133.1998.02187.x

Cited by 36 publications

(19 citation statements)

References 4 publications

(7 reference statements)

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“…EMPD may be associated with underlying anal and colorectal cancer [12] for perianal lesions and genitourinary malignancies [16, 17] for penoscrotal lesions. The reported incidence in Western literature ranged from 18% to 37% [12, 13, 16].…”

Section: Discussionmentioning

confidence: 99%

Extramammary Paget’s Disease: 20 Years of Experience in Chinese Population

Chan

Chung

et al. 2012

International Journal of Surgical Oncology

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Background. To examine the results of treatment of Extramammary Paget's disease (EMPD) in ethnic Chinese. Method. Between 1990 and 2010, patients treated for EMPD were reviewed. Data were analyzed retrospectively. Results. Forty-eight patients were treated by surgical resection. Local recurrence rate was 14.6%. The postresection defects were repaired by primary closure (8.3%), partial thickness skin graft (72.9%), or local/regional flaps (18.8%). Dermal invasion was found in 9 patients (18.8%). Seven patients (14.6%) developed regional lymph node metastasis (concurrent with surgery, n = 1; subsequent to surgery, n = 6), and 3 patients (6.3%) had systemic metastasis after surgery. The presence of dermal invasion was associated with significantly higher incidence of regional lymph nodes and systemic metastasis. The incidence of associated internal malignancy was 8.3%. Conclusion. The mainstay of treatment for EMPD is surgery. Pathological dermal invasion increases the chance of regional lymph node as well as systemic metastasis. The association with internal malignancy warrants preoperative endoscopic examination in all patients.

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Section: Discussionmentioning

confidence: 99%

Extramammary Paget’s Disease: 20 Years of Experience in Chinese Population

Chan

Chung

et al. 2012

International Journal of Surgical Oncology

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“…98 EMPD may also be associated with an underlying cutaneous adnexal carcinoma, usually an apocrine adenocarcinoma. 23 In up to 30% of cases, it represents metastatic spread from a regional visceral malignancy, such as cervical 99 rectal, 100 prostate 101 or transitional cell carcinoma, 102 in which case the tumour cells are positive to CK 7 and possibly GCDFP-15, 98 but they also demonstrate immunohistochemical profile similar to the original carcinoma, including positivity to CK 20 or CA19.9 in genitourinary or gastrointestinal carcinomas, 23 or prostatespecific antigen in prostate cancer. 101 An underlying regional visceral malignancy or cutaneous adnexal carcinoma is more commonly seen in perianal EMPD compared with the vulvar variant.…”

Section: Extramammary Paget's Diseasementioning

confidence: 99%

Skin adnexal neoplasms—part 2: An approach to tumours of cutaneous sweat glands

2006

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Tumours of cutaneous sweat glands are uncommon, with a wide histological spectrum, complex classification and many different terms often used to describe the same tumour. Furthermore, many eccrine/apocrine lesions coexist within hamartomas or within lesions with composite/mixed differentiation. In addition to the eccrine and apocrine glands, two other skin sweat glands have recently been described: the apoeccrine and the mammary-like glands of the anogenital area. In this review (the second of two articles on skin adnexal neoplasms), common as well as important benign and malignant lesions of cutaneous sweat glands are described, and a summary for differentiating primary adnexal neoplasms from metastatic carcinoma is outlined, striving to maintain a common and acceptable terminology in this complex subject. Composite/mixed adnexal tumours are also discussed briefly.

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“…Two previous studies (18, 19) have on the basis of a positive PSA in the EMPD skin lesion concluded that the lesion either had developed synchronously with or represented a cutaneous metastasis from the prostate cancer. We doubt that the skin lesions in EMPD represent an extension or a cutaneous metastasis from a prostate cancer in all cases.…”

Section: Discussionmentioning

confidence: 99%

Prostate‐specific antigen‐positive extramammary Paget's disease––association with prostate cancer

Hammer

Hager

Steiniche

2008

APMIS

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Extramammary Paget's disease (EMPD) is a rare intraepidermal adenocarcinoma that primarily affects the anogenital region. Cases of EMPD reacting with PSA (prostate-specific antigen) have previously been associated with underlying prostate cancer. However, a recent case of EMPD in our department has led us to question the value of PSA as an indicator of underlying prostate cancer. Clinical and pathological data were obtained for 16 cases of EMPD. Formalin-fixed, paraffin-embedded tissue blocks from the primary skin lesions were investigated using PSA and other immunohistochemical markers. 5 of the 16 cases of EMPD stained positive for PSA (2 women and 3 men). However, no reactivity was seen for the prostatic marker P501S. Three of the five patients had been diagnosed with internal malignant disease-two with prostate cancer, stage 1. Immunohistochemical investigations of the tumour specimens from the prostate revealed an immunoprofile which was very different from that of the primary skin lesion. In our study, no cases of EMPD with PSA positivity seem to represent an extension of an underlying prostatic adenocarcinoma. PSA positivity can be seen in cases of EMPD without associated adenocarcinoma of the prostate.

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Paget's disease of the scrotum: a case exhibiting positive prostate-specific antigen staining and associated prostatic adenocarcinoma

Cited by 36 publications

References 4 publications

Extramammary Paget’s Disease: 20 Years of Experience in Chinese Population

Extramammary Paget’s Disease: 20 Years of Experience in Chinese Population

Skin adnexal neoplasms—part 2: An approach to tumours of cutaneous sweat glands

Prostate‐specific antigen‐positive extramammary Paget's disease––association with prostate cancer

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