Paget’s Disease of the Nipple Resembling an Acantholytic Disease on Microscopic Examination

Wolf, Ronni; Bernstein-Lipschitz, Liora; Rothem, A.

doi:10.1159/000248100

Cited by 10 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two isolated reports in the literature describe prominent acantholysis in PD; in one, the diagnosis was initially rendered as pemphigus vulgaris and only a third biopsy of an erosive lesion on the nipple established the correct diagnosis; however, there is no mention of any anaplastic appearance of the cells. In the other case where there was no underlying mass, upon further investigations, the diagnosis of PD was established 8,9 . Therefore, presence of marked anaplasia and acantholysis may not be codependent.…”

Section: Discussionmentioning

confidence: 99%

“…In the other case where there was no underlying mass, upon further investigations, the diagnosis of PD was established. 8,9 Therefore, presence of marked anaplasia and acantholysis may not be codependent. One of our cases developed PD in the nipple 5 years after lumpectomy, despite negative surgical margins and no vascular or metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acantholytic anaplastic Paget’s disease

Mobini

2009

J Cutan Pathol

View full text Add to dashboard Cite

Classic Paget's disease (PD) can be diagnosed relatively easily by histopathologic examination. 'Anaplastic' variant of this disease is a less-recognized subset that may pose as a diagnostic challenge and pitfall. We describe two cases who presented with scaly erythematous plaques on their nipple/areola. In the first patient, there was no palpable mass and imaging studies were negative. The second case presented with a lesion 5 years after a lumpectomy. Initial shave biopsies revealed histopathologic changes indistinguishable from Bowen's disease with no readily identifiable classic Paget's cells, associated with prominent superficial acantholysis. The neoplastic cells were negative for mucin, GCDFP-15, negative/minimally positive for CEA and strongly positive for CK7 markers. A high-grade ductal carcinoma in situ in the underlying breast was ultimately found in both cases. Anaplastic PD is a rare variant of this disease that histologically mimics Bowen's disease with an associated prominent superficial acantholysis. There is mucin, CEA and GCDFP-15 negativity with positive CK7 reaction. A high index of suspicion along with a complete immunohistochemical panel should be considered in evaluating any Bowenoid neoplasm of the breast skin, particularly in superficial skin shave biopsies along with negative imaging studies and no palpable mass clinically.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acantholytic anaplastic Paget’s disease

Mobini

2009

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…Wolf et al reported Paget's disease that resembled pemphigus in a woman that was unsuccessfully treated for 8 months with an erosive, oozing lesion on her nipple (6). Initially pathologic evaluations of the localized tissue specimens from the areolar borders were suggestive of pemphigus, but immunohistochemical analyses proved to be negative.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus Vulgaris Mimicking Paget's Disease of the Breast

2003

View full text Add to dashboard Cite

We report the development of an ulcerative skin lesion involving the areola of a 37-year-old woman. Clinically the lesion was compatible with Paget's disease, however, histologic evaluation identified pemphigus vulgaris. Differences in the presentation and treatment of these two entities are highlighted. The underlying role of plasminogen activator in the molecular pathology of both diseases is discussed.

show abstract

“…16A-B), which likely constitutes a nonspecific change in the epidermis, resulting in loss of intercellular adhesions. 74,75 ,…”

Section: Histopathologymentioning

confidence: 99%

Nipple Lesions of the Breast

Brogi,

Scatena

2023

Advances in Anatomic Pathology

View full text Add to dashboard Cite

Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ectasia or be the site of uncommon superficial epithelial neoplasms such as nipple adenoma or syringomatous tumor of the nipple. Paget disease of the nipple may be secondary to intraepidermal extension of ductal carcinoma in situ in the underlying lactiferous ducts or develop from malignant transformation of Toker cells. Invasive breast cancer may also arise primarily in the nipple. Most of these conditions present as a palpable mass and/or skin changes with or without nipple discharge. Due to the delicate location and often relatively small size of nipple lesions, biopsy specimens are often superficial and fragmented, and the interpretation is challenging. Knowledge of the morphologic and immunophenotypic features of nipple lesions is essential in making the correct diagnosis. Information on the molecular alterations underpinning nipple neoplasms is currently very limited.

show abstract

Paget’s Disease of the Nipple Resembling an Acantholytic Disease on Microscopic Examination

Cited by 10 publications

References 3 publications

Acantholytic anaplastic Paget’s disease

Acantholytic anaplastic Paget’s disease

Pemphigus Vulgaris Mimicking Paget's Disease of the Breast

Nipple Lesions of the Breast

Contact Info

Product

Resources

About