Paget's Disease of the Gians penis: An Unusual Urological Malignancy

Extramammary Paget's Disease: A Report of 22 Cases in Chinese Males

“…Fifty to eighty-six percent of patients with perianal Paget's disease had associated colorectal malignancy (2). Although Paget's disease of the glans penis is rarely reported in the literature (17)(18)(19)(20)(21)(22)(23)(24)(25)(26), many cases have been associated with transitional cell carcinoma of the bladder. Genital Paget's disease without involvement of the glans penis is more commonly described, but is rarely associated with internal malignancy (27)(28)(29)(30)(31)(32).…”

Penile Preservation Surgery in a Case of Extramammary Paget's Disease Involving the Glans Penis and Distal Urethra

“…As stated earlier, to our knowledge, 11 cases of EMPD involving the glans penis have thus far been reported (Table 1). Only 1 case (9%) 13 was an extension of male genital Type 1b EMPD; the remaining 10 cases (91%) [4][5][6][7][8][9][10][11][12] were Type 3 EMPD associated with genitourinary carcinoma. Six of 8 cases (75%) 4,5,9,11,12 with Type 3 EMPD involving the glans penis died of the disseminated primary tumor within a year.…”

“…Six of 8 cases (75%) 4,5,9,11,12 with Type 3 EMPD involving the glans penis died of the disseminated primary tumor within a year. For 9 of the cases, local treatment was mentioned: 6 cases were treated with penectomy, 4,5,9,10,12,13 2 cases with resection, 6,7 and 12 3 Prostate cancer Partial penectomy 1 year Dead Turner 5 3 Bladder cancer Amputation 1 year Dead Metcalf 6 3 Bladder cancer Resection NS NS Powell 7 3 Bladder cancer Resection NS NS Tomaszewski 8 3 Bladder cancer YAG laser ablation 1 year Alive Jenkins 9 3 Bladder cancer Circumferential excision 6 months Dead Smith 10 3 Bladder cancer Partial penectomy 4 years Alive Salamanca 11 3 1 case with laser ablation. 8 The role of laser ablation in EMPD is still not defined because the follow-up time is insufficient to assess the success rate of this modality.…”

“…The standard therapy of EMPD is excision to subcutaneous tissue deep enough to remove all cutaneous adnexal structures. EMPD involving the glans penis is very rare: to our knowledge, in the English language journals accessible via MEDLINE, only 11 cases [4][5][6][7][8][9][10][11][12][13] have been reported of 150 cases of male genital EMPD. The standardized treatment of this condition, therefore, has not been well discussed, with up to 60% of reported cases treated with penectomy.…”

“…2 Secondary EMPD is defined as involvement of the genital skin by noncutaneous internal malignancies such as anal or rectal adenocarcinoma 3 and transitional cell carcinoma of the urethra or bladder. [4][5][6][7][8][9][10][11] Primary EMPD is generally a slow-growing malignancy and considered to be a relatively benign disease. The standard therapy of EMPD is excision to subcutaneous tissue deep enough to remove all cutaneous adnexal structures.…”