Pagetʼs Disease of the Esophagus A Case Report with Review of the Literature

Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus

“…The latter can be demonstrated by a positive histochemical reaction for epithelial mucin and/or a positive immunohistochemical reaction for CEA or cytokeratin 7. In addition to the present case, three previous reports 11–13 also fulfilled these criteria. The first case report of oesophageal Paget's disease, 10 according to the table provided by Matsukuma et al ., 13 however, did not fulfil all the criteria of Paget's disease.…”

“…In addition to the present case, three previous reports 11–13 also fulfilled these criteria. The first case report of oesophageal Paget's disease, 10 according to the table provided by Matsukuma et al ., 13 however, did not fulfil all the criteria of Paget's disease. The pagetoid cells in their case, like ours, showed a negative reaction for mucin, but unlike ours and other reported cases 11–13 no immunohistochemistry was done.…”

“…The first case report of oesophageal Paget's disease, 10 according to the table provided by Matsukuma et al ., 13 however, did not fulfil all the criteria of Paget's disease. The pagetoid cells in their case, like ours, showed a negative reaction for mucin, but unlike ours and other reported cases 11–13 no immunohistochemistry was done. In view of the underlying poorly differentiated squamous cell carcinoma in their case, the cancer cells in the surface epithelium probably represented pagetoid spread rather than Paget's disease.…”

“…Oesophageal Paget's disease, like other extramammary sites, however, is rare. A Medline ® search of the English literature has yielded only four cases, 10–13 to which we are adding the fifth case.…”

Extramammärer Morbus Paget – Klinik, Histogenese, Therapiemöglichkeiten

“…Zu weiteren Lokalisationen, in denen der Tumor allerdings nur ganz vereinzelt beschrieben werden konnte, zählen die Lider, der äußere Gehörgang, die Nabelregion, der Stamm und die Extremitäten [21][22][23][24][25][26][27]. In Einzelfällen wurde der EMP auch in verschiedenen Schleimhautlokalisationen (u. a. Zunge, Bronchien, Ösophagus und Urethra) beobachtet [25][26][27]. Ebenfalls als Rarität gelten multilokuläre Manifestationen des Tumors mammär und extramammär oder extramammär in verschiedenen Lokalisationen, z.…”