Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus

Haleem, Abdul; Kfoury, Hala; Juboury, Muna Al; Husseini, H Al

doi:10.1046/j.1365-2559.2003.01514.x

Cited by 16 publications

(13 citation statements)

References 26 publications

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“…[17][18][19][20][21] Considering their rarity, whether there is a stepwise process from adenoma to adenocarcinoma remains uncertain. Initially, GERD affects the esophagus rendering increased pressure of the esophageal cavity and inflammatory cells infiltration of the normal esophageal mucosa and SMGs.…”

Section: Discussionmentioning

confidence: 99%

“…If the GERD persists, dilation of the ESGD and atrophy of the acini become evident. Simultaneously, with the long-term stimulation of the retained content and inflammatory cells, the primitive precursor cells [17][18][19][20][21] Considering their rarity, whether there is a stepwise process from adenoma to adenocarcinoma remains uncertain. It is noteworthy that microscopic esophagitis suggesting GERD is constantly observed.…”

Section: Discussionmentioning

confidence: 99%

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Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Nie

Shen

et al. 2015

Dis Esophagus

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Esophageal submucosal gland duct adenoma (ESGDA) is a rare tumor. The clinicopathological features of the ESGDA and its precursor lesion have not been comprehensively evaluated. In this study, we aimed at delineating the clinicopathological features of the ESGDA and cyst formation of the esophageal submucosal gland duct (ESGD), as well as their correlations and clinical implications. We identified three cases of ESGDA and 16 cases of cyst formation of the ESGD among 786 endoscopic mucosal resection specimens over a 7-year period. The median patient age was 58 years with a male predominance. These lesions were small submucosal bulges locating at the lower esophagus with a size no more than 1 cm. The main microscopic changes of these lesions included content retention, multilayered epithelium or papillary folds of the ESGD and inflammatory cell infiltration, acidophilic degeneration, hyperplasia or atrophy of the acini. The included cases generally showed moderate to severe microscopic esophagitis. The ESGDA was mainly consisted by multiple glandular cysts covered by two layers of cells. Immunohistochemical results showed that the luminal duct lining cells and basal cells were positive for CK7 and p63, respectively. Both of the two layer cells were positive for HMWCK and negative for CK20, p53, CDX2, MUC5AC, MUC6, MUC2 and MUC1. The proliferation index was very low (1%). The diagnostic criteria of the ESGDA were proposed and, the differential diagnosis was discussed. Cyst formation of the ESGD is considered to be the precursor lesion of the ESGDA, because they have overlapping clinicopathological features with progressive relationship. In addition, the ESGDA have close connection with advance of the GERD and, probably, an increased risk of carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Nie

Shen

et al. 2015

Dis Esophagus

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“…Purely mucous membrane EMPD has been rarely observed in the ureter (in association with prostatic and urinary bladder cancers), the larynx, the oesophagus (in association with invasive epidermoid carcinoma of its lower part), 67 the bronchial tree and the oral mucosa (associated with adenocarcinoma of the bronchial 33 and salivary glands, 68 respectively).…”

Section: Extramammary Paget's Diseasementioning

confidence: 99%

Mammary and extramammary Paget's disease

Kanitakis

2007

Acad Dermatol Venereol

274

287

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Paget's disease is an intra-epidermal adenocarcinoma seen over the nipple/areola (mammary Paget's disease) or in extramammary body zones, such as the anogenital and perineal skin and the axilla. Mammary and extramammary Paget's disease share many common clinicopathological features but also show several differences, namely, with regard to pathogenesis and association with underlying malignancies. Indeed, mammary Paget's disease is as a rule associated with an underlying breast carcinoma whereas association of extramammary Paget's disease with underlying (skin or visceral) malignancies occurs much less frequently. We review here the main clinicopathological and therapeutic features of mammary and extramammary Paget's disease.

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“…In some instances, the term ‘secondary’ EPD has been used to refer to some visceral carcinomas exhibiting epidermotropism resulting in intraepidermal invasion or metastasis, the so‐called Pagetoid phenomenon 4 . As previously reported, most of these phenomena are associated with recognizable adenocarcinoma of the underlying glandular tissue 5 . Pagetoid spread of anal canal carcinoma including rectal and anal gland types was present in at least one case 6 .…”

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confidence: 90%

Anal canal neuroendocrine carcinoma with Pagetoid extension

Guo

Miyazaki

Jin

et al. 2004

Pathology International

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A case of anal canal neuroendocrine carcinoma with Pagetoid intraepithelial extension is presented. An 80-year-old man was admitted to hospital with a complaint of pain in the anorectal region. Clinical examination revealed a hard and fixed mass in the anal canal, and subsequent biopsy of the lesion showed it to be a carcinoma. The surgically resected specimen showed a solid tumor measuring 3.4 x 3.2 cm within the area from the surgical anal canal to the anatomical anal canal. Tumor cells proliferated predominantly with compact nests. Many tumor cells had a high nuclear-to-cytoplasmic ratio, dispersed chromatin, and conspicuous nucleoli. Additionally, neoplastic cells focally formed a glandular structure. Some polygonal neoplastic cells were small with round nuclei. A rosette-like arrangement was also focally observed. In addition, tumor cells exhibited Pagetoid extension into the overlying epithelium of the histological anal canal. Both the underlying original neoplastic cells and the Pagetoid spreading tumor cells showed cytoplasmic granules positive for Grimelius staining and immunopositivity for carcinoembryonic antigen, synaptophysin and cytokeratins 7 and 20. These findings are highly suggestive of neuroendocrine differentiation of adenocarcinoma cells. To the best of our knowledge, this is the first case of anal canal neuroendocrine carcinoma with Pagetoid extension into the overlying epithelium of the histological anal canal.

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Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus

Abstract: As far as we know, this is the fifth case report of oesophageal Paget's disease and the first report of its association with the underlying mucous gland carcinoma.

Cited by 16 publications

References 26 publications

Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Mammary and extramammary Paget's disease

Anal canal neuroendocrine carcinoma with Pagetoid extension

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