Paget phenomenon of the vulva with histopathological features of high-grade urothelial carcinoma (transitional cell carcinoma)

Kurashige, Yuta; Minemura, Tokuya; Nagatani, Tetsuya

doi:10.1684/ejd.2013.2087

Cited by 2 publications

(3 citation statements)

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“…The usefulness of CK‐7, CK‐20, and GCDFP‐15 in EMPD diagnosis has been reported. 2 , 3 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 As CK‐7 is positive in primary and secondary EMPD, it could not be conclusive. Conversely, CK‐20 and GCDFP‐15 were useful in diagnosing secondary EMPD.…”

Section: Discussionmentioning

confidence: 98%

“…For differential diagnosis, immunohistological analysis was useful. The usefulness of CK‐7, CK‐20, and GCDFP‐15 in EMPD diagnosis has been reported 2,3,6–15 . As CK‐7 is positive in primary and secondary EMPD, it could not be conclusive.…”

Section: Discussionmentioning

confidence: 99%

“…reported. 2,3,[6][7][8][9][10][11][12][13][14][15] As CK-7 is positive in primary and secondary EMPD, it could not be conclusive. Conversely, CK-20 and GCDFP-15 were useful in diagnosing secondary EMPD.…”

Section: Ndmentioning

confidence: 99%

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Pagetoid spread of urothelial carcinoma controlled without resection

et al. 2022

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Introduction Extramammary Paget's disease is an eczematous skin condition that affects the vulva and perineum. Extramammary Paget's disease secondary to urothelial carcinoma is a rare condition that is typically treated with invasive surgical resection of the lesion. Case presentation An 80‐year‐old woman with a 7‐year history of urothelial carcinoma presented with erythema of the labia majora. Immunostaining of skin biopsy specimens suggested extramammary Paget's disease secondary to urothelial carcinoma. The patient did not consent to resection of the lesion. Nine cycles of first‐line platinum‐based chemotherapy for metastatic urothelial carcinoma were administered. As tumor cells remained after systemic chemotherapy, pembrolizumab will be administered to the patient for treating residual extramammary Paget's disease. Conclusion Platinum‐based chemotherapy can control extramammary Paget's disease secondary to urothelial carcinoma.

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