Paget bone disease demonstrated on 68Ga-PSMA ligand PET/CT

PSMA-PET/CT-Positive Paget Disease in a Patient with Newly Diagnosed Prostate Cancer: Imaging and Bone Biopsy Findings

“…Endothelial expression of PSMA in neovasculature known to occur in Paget disease has been postulated as the mechanism causing the PSMA-PET/CT positivity of this condition [5–8]. In the current case, we found some confirming evidence for this assumption with a weak PSMA positivity of endothelial cells in the bone affected by Paget disease (Figure 2(d)).…”

“…68 Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) showed moderate PSMA positivity of this lesion (Figure 1(b)). Since Paget disease has been reported to cause PSMA positivity bone lesions [5–8], a bone biopsy was obtained for final workup that confirmed the diagnosis of Paget disease (Figure 2). After radical prostatectomy (pT3bpN0), PSA fell below the lowest detection level ruling out gross bone metastases.…”

Elevated 68Ga Prostate-Specific Membrane Antigen Activity in Metastatic Non–Small Cell Lung Cancer

“…8 Prostate-specific membrane antigen expression has also been reported in nonmalignant conditions such as sarcoidosis and Paget disease of the bone. 11,12 …”

PSMA Ligands for PET Imaging of Prostate Cancer

“…Accordingly, there is increasing evidence that PSMA ligand uptake is not exclusively specific for PC. A large number of case series and reports describe increased PET signal in benign lesions (e.g., neurogenic tissue, Paget disease, thyroid adenoma, granulomatous disease, and adrenal adenoma) as well as in malignant diseases (e.g., renal cell carcinoma, lung cancer, glioblastoma, hepatocellular carcinoma, and thyroid cancer) (87)(88)(89)(90)(91)(92)(93)(94)(95). Supplemental Table 1 (supplemental materials are available at http://jnm.snmjournals.org) summarizes the current evidence in the literature.…”