Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway

Zhang, Qiang; Yuan, Yonghui; Cui, Jianchun; Xiao, Tingting; Jiang, Daqing

doi:10.1016/j.biopha.2016.01.019

Cited by 52 publications

(49 citation statements)

References 17 publications

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“…Recent in‐vitro studies indicate that Paeoniflorin in various concentrations inhibits expression of HIF‐1α through regulating pathway PI3K/Akt, thus prevent against epithelial‐to‐mesenchymal transition (EMT) which is induced by hypoxia on breast cancer cell . Another study indicates that Paeoniflorin inhibits proliferation and invasion of human breast cancer cell lines MDA‐MB‐231 and MCF‐7 through inhibiting pathway Notch1 . In 2018, Zhang et al .…”

Section: Anticancer Activities Of Paeoniflorin and Its Potential Mechmentioning

confidence: 99%

“…[36] Another study indicates that Paeoniflorin inhibits proliferation and invasion of human breast cancer cell lines MDA-MB-231 and MCF-7 through inhibiting pathway Notch1. [37] In 2018, Zhang et al [38] found that Paeoniflorin in low concentration successfully inhibits proliferation and invasion of human breast cancer cell line MCF-7 through inhibiting pathway Notch1, then proved Paeoniflorin's antitumour effect additionally.…”

Section: Breast Cancermentioning

confidence: 99%

“…Paeoniflorin inhibits activity of gastric cancer cell MGC-803 and induces apoptosis, through up-regulating miR-124 and inhibiting pathways of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and signal-activated transcription factors 3 (STAT3) [33] 2.5, 5, 10 lg/ml Gastric cancer fibroblast GCAFs Inhibit metastasis and invasion of GCAFs through targeted inhibition of pathway IL-6-STAT3-MMP [33] Breast cancer 12.5-50 lmol/l Human breast cancer cell lines MDA-MB-231 and MCF-7 PF inhibits expression of HIF-1a through regulating pathway PI3K/Akt, protects against breast cancer cell hypoxia-induced epithelial-to-mesenchymal transition (EMT) [36] Inhibit proliferation and invasion of breast cancer cell through inhibiting pathway Notch-1 [37] 0, 7.5, 15, 30 lmol/l Breast cancer cell line MCF-7 Inhibit proliferation and invasion of breast cancer cell through inhibiting pathway Notch-1 [38] Lung cancer 40 mg/kg per day Lewis lung carcinomabearing mice model Inhibit tumour growth of Lewi lung carcinoma-bearing mice, and inhibit lung metastasis of Lewi lung carcinoma-bearing mice [40] 1, 3, 10, 30, 100 lmol/l; 20, 40 mg/kg…”

Section: Human Gastric Cancer Cell Line Sgc7901vincristine Vcrmentioning

confidence: 99%

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Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

Xiang

Zhang

Wei

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Paeoniflorin, a representative pinane monoterpene glycoside in plants of Paeoniaceae family, possesses promising anticancer activities on diverse tumours. This paper summarized the advance of Paeoniflorin on cancers in vivo and in vitro, discussed the related molecular mechanisms, as well as suggested some perspectives of the future investigations. Key findings Anticancer activities of paeoniflorin have been comprehensively investigated, including liver cancer, gastric cancer, breast cancer, lung cancer, pancreatic cancer, colorectal cancer, glioma, bladder cancer and leukaemia. Furthermore, the potential molecular mechanisms corresponding to the antitumour effects of Paeoniflorin might be related to the following aspects: inhibition of tumour cell proliferation and neovascularization, induction apoptosis, and inhibition of tumour invasion and metastasis. Summary Paeoniflorin has wide spectrum antitumour activities; however, in vivo and clinical investigations on antitumour effect of Paeoniflorin are lacking which should be focused on further studies. Our present review on antitumour effects of Paeoniflorin would be beneficial for the further molecular mechanisms study, candidate antitumour drug development and clinical research of Paeoniflorin in the future.

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Section: Anticancer Activities Of Paeoniflorin and Its Potential Mechmentioning

confidence: 99%

Section: Breast Cancermentioning

confidence: 99%

Section: Human Gastric Cancer Cell Line Sgc7901vincristine Vcrmentioning

confidence: 99%

See 1 more Smart Citation

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

Xiang

Zhang

Wei

et al. 2019

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Paeoniflorin upregulated apoptosis of MGC‐803 human gastric carcinoma cells and HT29 human colorectal cancer cells (Chen, Lee, et al, ; Parker et al, ; Zheng et al, ). It inhibited proliferation, invasion, and metastasis of MCF‐7/MDA‐MB‐231 human breast cancer cells and human A549 lung cancer cells (Parker et al, ; Zhang, Yuan, Cui, Xiao, & Jiang, ; Zhou, Wang, Song, & Hu, ). The astragalin contained in P. lactiflora induces apoptosis in A375P and SK‐MEL‐2 melanoma cells (You et al, ).…”

Section: Discussionmentioning

confidence: 99%

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Deng

Sun

2018

Phytotherapy Research

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The aims of this study were to evaluate the efficacy of herbal medicine for the prevention and management of hand-foot syndrome (HFS) induced by fluoropyrimidines and to identify herbs associated with HFS alleviation for further research. The PubMed, Cochrane, Springer, China National Knowledge Infrastructure, and Wanfang databases were searched up to May 2017 for randomized controlled trials (RCTs) that evaluated herbal medicine for relieving HFS in patients undergoing fluoropyrimidine-based chemotherapy. Study evaluation and synthesis methods were in accordance with the Cochrane Handbook, and data were analyzed using RevMan 5.3. In total, 35 RCTs (2,668 participants) were included. Meta-analysis showed that the addition of herbal medicine significantly reduced the incidences of all-grade and high-grade HFS. The total effective rate and complete remission rate of HFS patients increased significantly with herbal medicine arm. Further sensitivity analysis identified Paeoniae Radix Alba, Carthami Flos, Cinnamomi Ramulus, and Glycyrrhizae Radix et Rhizoma as being consistently associated with significant reductions in HFS incidence without important heterogeneity. However, the lack of blinding in most studies may have led to overestimation of these effects. More high-quality RCTs and experimental research are needed to confirm and investigate the efficacy of the herbs identified in this study.

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“…5 Emerging studies have reported that PF possesses diverse pharmacological activities, such as neuroprotective, anti-inflammatory, antioxidative, immunoregulatory, antitumor, and antiallergic effects. [6][7][8] For example, Sun et al 9 reported that PF treatment dramatically decreased airway hyperresponsiveness to aerosolized methacholine and downregulated the levels of interleukin-5 (IL-5), IL-13, IL-17, and eotaxin in the bronchoalveolar lavage fluid of asthmatic mice. However, the roles of PF in activated human mast cell line, HMC-1 cells, have not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Paeoniflorin inhibits mast cell–mediated allergic inflammation in allergic rhinitis

Wang

Cheng

2018

J of Cellular Biochemistry

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Paeoniflorin (PF), one of the main effective ingredients from the root of Paeonia lactiflora Pall., was reported to possess antitumor, anti-inflammatory, and antiallergic properties. However, the roles of PF in activated human mast cell line, HMC-1 cells, have not yet been elucidated. Thus, the aim of this study was to examine the antiallergic and anti-inflammatory effects of PF on phorbol-12-myristate 13-acetate plus calcium ionophore (PMACI)-induced human mast cells and to identify the mechanism responsible for these effects. Our results demonstrated that pretreatment with PF effectively attenuated PMACI-induced production of tumor necrosis factor-α and interleukin 1β in HMC-1 cells. In addition, PF significantly suppressed PMACI-induced histamine release and caspase-1 activation in HMC-1 cells. Furthermore, PF prevented the activation of nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways in activated HMC-1 cells. In conclusion, we showed for the first time that PF attenuated the mast cell-mediated allergic inflammatory response through suppressing the NF-κB and MAPK signaling pathways.

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Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway

Cited by 52 publications

References 17 publications

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Paeoniflorin inhibits mast cell–mediated allergic inflammation in allergic rhinitis

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