Paeoniflorin: a monoterpene glycoside from plants of <i>Paeoniaceae</i> family with diverse anticancer activities

Xiang, Yongjing; Zhang, Qing; Wei, Shujun; Huang, Cong; Li, Zhengsheng; Gao, Yongxiang

doi:10.1111/jphp.13204

Cited by 60 publications

(35 citation statements)

References 78 publications

(151 reference statements)

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“…Paeoniae radix is the root of Paeonia lactiflora, a herbaceous perennial plant belonging to the family Paeoniaceae (27). Paeoniflorin, a monoterpene glycoside, is one of the major active components of Paeoniae radix.…”

Section: Discussionmentioning

confidence: 99%

A 12-week, randomized, double-blind, placebo-controlled study assessing the efficacy of EGHB010, a standardized extract of Paeoniae radix and Glycyrrhizae radix, in patients with early age-related macular degeneration

Kim¹,

Kim²,

Kim³

et al. 2021

Ann Transl Med

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Background: EGHB010, a standardized extract of Paeoniae radix and Glycyrrhizae radix, inhibits choroidal neovascularization. The aim of this study is to evaluate the efficacy and safety of EGHB010 on early agerelated macular degeneration (AMD) progression inhibition. Methods:The study was designed as a randomized, double-blind, single-center, placebo-controlled study.Subjects were 50 years of age or older, and early AMD satisfied the criteria of more than 15 small (<63 µm) drusen, less than 20 intermediate (≥63, <125 µm) drusen, or pigment abnormalities. For 12 weeks, the treatment group received EGHB010 and the control received the placebo. The main outcomes were changes in macular pigment optical density (MPOD), central macular thickness (CMT), and central choroidal thickness (CCT). Subgroup analysis was performed on subjects with MPOD <0.75 at baseline.Results: Forty-eight subjects out of 94 were assigned to the treatment group, and 46 to the control group.At 12 weeks, mean MPOD of the treatment group increased by 0.04±0.27 (P=0.2730), and that of the control group decreased by 0.03±0.21 (P=0.7240), but there was no significant difference between the two groups (P=0.1234). There were no significant differences between the two groups in mean CMT and CCT (P=0.6718 and 0.6608, respectively). In subgroup analysis, there were 39 subjects with MPOD <0.75 in the treatment group and 36 in the control. Mean MPOD of the treatment group significantly increased by 0.09±0.25 (P=0.0218), and there was a significant difference in mean MPOD at 12 weeks between the two groups (P=0.0248). Adverse reactions were similar in both groups, and no subjects had serious adverse events.Conclusions: EGHB010 is expected to increase MPOD when administered to subjects with MPOD <0.75. EGHB010 is worth considering as a substance that inhibits the progression of early AMD.

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Section: Discussionmentioning

confidence: 99%

A 12-week, randomized, double-blind, placebo-controlled study assessing the efficacy of EGHB010, a standardized extract of Paeoniae radix and Glycyrrhizae radix, in patients with early age-related macular degeneration

Kim¹,

Kim²,

Kim³

et al. 2021

Ann Transl Med

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“…Paeoniflorin is a monoterpene glycoside with various anti-cancer activities and is derived from Paeonia lactiflora . Studies have shown that paeoniflorin has broad-spectrum anti-tumor activities against various cancers ( 76 ), including those of liver ( 77 ), lungs ( 78 ), breast ( 79 ), and pancreas ( 80 ). miR-124 levels are significantly increased in paeoniflorin-treated MGC-803 cells, which inhibits PI3K/Akt and p-STAT3 expression.…”

Section: Active Ingredients Of Chinese Medicine Targeting Mirna Inhibmentioning

confidence: 99%

Anti-Tumor Mechanisms Associated With Regulation of Non-Coding RNA by Active Ingredients of Chinese Medicine: A Review

Liu

Qiu

et al. 2021

Front. Oncol.

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Cancer has become the second leading cause of death worldwide; however, its complex pathogenesis remains largely unclear. Previous research has shown that cancer development and progression are closely associated with various non-coding RNAs, including long non-coding RNAs and microRNAs, which regulate gene expression. Target gene abnormalities are regulated and engaged in the complex mechanism underlying tumor formation, thereby controlling apoptosis, invasion, and migration of tumor cells and providing potentially effective targets for the treatment of malignant tumors. Chemotherapy is a commonly used therapeutic strategy for cancer; however, its effectiveness is limited by general toxicity and tumor cell drug resistance. Therefore, increasing attention has been paid to developing new cancer treatment modalities using traditional Chinese medicines, which exert regulatory effects on multiple components, targets, and pathways. Several active ingredients in Chinese medicine, including ginsenoside, baicalin, and matrine have been found to regulate ncRNA expression levels, thus, exerting anti-tumor effects. This review summarizes the scientific progress made regarding the anti-tumor mechanisms elicited by various active ingredients of Chinese medicine in regulating non-coding RNAs, to provide a theoretical foundation for treating tumors using traditional Chinese medicine.

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“…Growing evidence indicates the potential of natural compounds to serve as successful anticancer agents [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Analysis and construction of a competitive endogenous RNA regulatory network of baicalin-induced apoptosis in human osteosarcoma cells

Lan

Wang

Gao

et al. 2021

Preprint

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Background: Baicalin is an extract from the traditional Chinese herb Scutellaria baicalensis. Recent literature reports have shown the potential of baicalin to treat osteosarcoma (OS). However, the transcriptome-level mechanism of baicalin-mediated antitumor effects in OS has not yet been investigated. The aim of this study was to analyze the competitive endogenous RNA (ceRNA) regulatory network involved in baicalin-induced apoptosis of OS cells.Methods: In this study, CCK-8 and flow cytometry assays were used to detect the antitumor effects of baicalin on human OS MG63 cells. Furthermore, whole transcriptome sequencing was employed to establish the long noncoding RNA (lncRNA), microRNA (miRNA), and mRNA profiles.Results: Baicalin could inhibit MG63 cell proliferation and could induce apoptosis. A total of 58 lncRNAs, 31 miRNAs, and 2136 mRNAs in the baicalin-treated MG63 cells were identified as differentially expressed RNAs compared to those in control cells. Of those, 2 lncRNAs, 3 miRNAs, and 18 mRNAs were included in the ceRNA regulatory network. The differentially expressed RNAs were confirmed by using quantitative real-time PCR (qRT-PCR). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to identify the target genes and signaling pathways of the aberrantly expressed RNAs.Conclusions: By identifying the ceRNA network, our results provide new information about the possible molecular basis of baicalin, which might be able to be used for OS treatment.

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Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

Cited by 60 publications

References 78 publications

A 12-week, randomized, double-blind, placebo-controlled study assessing the efficacy of EGHB010, a standardized extract of Paeoniae radix and Glycyrrhizae radix, in patients with early age-related macular degeneration

A 12-week, randomized, double-blind, placebo-controlled study assessing the efficacy of EGHB010, a standardized extract of Paeoniae radix and Glycyrrhizae radix, in patients with early age-related macular degeneration

Anti-Tumor Mechanisms Associated With Regulation of Non-Coding RNA by Active Ingredients of Chinese Medicine: A Review

Analysis and construction of a competitive endogenous RNA regulatory network of baicalin-induced apoptosis in human osteosarcoma cells

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