Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling

Abstract

In summary, the in vitro data suggest that paeoniflorin is a potential novel therapeutic agent against gastric carcinoma, which inhibits cell viability and induces apoptosis through the up-regulation of miR-124 and suppression of PI3K/Akt and STAT3 signaling.

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

“…Paeoniflorin inhibits activity of gastric cancer cell MGC-803 and induces apoptosis, through up-regulating miR-124 and inhibiting pathways of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and signal-activated transcription factors 3 (STAT3) [33] 2.5, 5, 10 lg/ml Gastric cancer fibroblast GCAFs Inhibit metastasis and invasion of GCAFs through targeted inhibition of pathway IL-6-STAT3-MMP [33] Breast cancer 12.5-50 lmol/l Human breast cancer cell lines MDA-MB-231 and MCF-7 PF inhibits expression of HIF-1a through regulating pathway PI3K/Akt, protects against breast cancer cell hypoxia-induced epithelial-to-mesenchymal transition (EMT) [36] Inhibit proliferation and invasion of breast cancer cell through inhibiting pathway Notch-1 [37] 0, 7.5, 15, 30 lmol/l Breast cancer cell line MCF-7 Inhibit proliferation and invasion of breast cancer cell through inhibiting pathway Notch-1 [38] Lung cancer 40 mg/kg per day Lewis lung carcinomabearing mice model Inhibit tumour growth of Lewi lung carcinoma-bearing mice, and inhibit lung metastasis of Lewi lung carcinoma-bearing mice [40] 1, 3, 10, 30, 100 lmol/l; 20, 40 mg/kg…”

Inhibitory effects of bevacizumab monoclonal antibodies in combination with chemotherapy in different time sequences on a human gastric carcinoma cell line

“…Treatment with bevacizumab mAbs for 24 h prior to FP chemotherapy significantly increased the apoptotic ratio of cells in the S phase. Other studies showed that [16][17][18][19][20] cell cycle arrest in S phase can reduce the number of cells that undergo mitosis, interfere with DNA synthesis, and enhance the cytotoxicity of 5-FU, thereby increasing tumor cell apoptosis and inhibiting tumor cell growth and proliferation.…”

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

“…It also inhibited inflammatory pain via modulation of N‐methyl‐D‐aspartate in the brain cortex and reduced related cytokines, such as tumor necrosis factor‐α (TNF‐α), interleukin (IL)‐1β, IL‐6, IL‐10, IL‐12, and IL‐17 (Dai et al, ; Sun et al, ; Xu et al, ). Paeoniflorin upregulated apoptosis of MGC‐803 human gastric carcinoma cells and HT29 human colorectal cancer cells (Chen, Lee, et al, ; Parker et al, ; Zheng et al, ). It inhibited proliferation, invasion, and metastasis of MCF‐7/MDA‐MB‐231 human breast cancer cells and human A549 lung cancer cells (Parker et al, ; Zhang, Yuan, Cui, Xiao, & Jiang, ; Zhou, Wang, Song, & Hu, ).…”