Paeonenoides D and E: Two New Nortriterpenoids from Paeonia lactiflora and Their Inhibitory Activities on NO Production

Abstract

Tw onew nortriterpenoids,paeonenoides Dand E(1 and 2,resp.),together with seven known compounds,were isolated from the roots of Paeonia lactiflora.T heir structures were elucidated on the basis of spectroscopic evidence.C ompounds 1 -7 were screened for inhibitory effects against NO productioninLPS-induced RAW246.7 macrophages and for cytotoxic activities against HL-60,Hep-G2,and SK-OV-3cell lines.Compounds 1 -3 and 5 -7 exhibited inhibitory activities with IC 50 valuesinthe range of 9.6 -32.2 mm.T riterpenoids with an epoxide ring and af ree COOH function, 1 -3,s howede ffectively increased activities compared with other pentacyclic triterpenoids. Compounds 1 -6 showedsignificant cytotoxic activities against the Hep-G2cell line and modest cytotoxic activities against HL-60and SK-OV-3cell lines.

Monoterpene glycosides from Paeonia veitchii

“…Previously, we reported on the isolation and structural elucidation of monoterpene glycosides, dimeric monoterpene glycosides, and nortriterpenoids from P. lactiflora [4][5][6][7]. In present study, we report the isolation and structure elucidation of two new monoterpene glycosides and a new dimeric monoterpene glycoside from P. veitchii.…”

Design, Synthesis, and Evaluation of α‐(Hydroxymethyl)cycloalkanols

“…However, two new pentacyclic triterpenoids, paeonenoides D 6 a and E 6 b , recently isolated by Zou and coworkers from the roots of Paeonia lactiflora , exhibited inhibitory activities against NO production in LPS‐induced RAW 264.7 macrophages with IC 50 values in the range of 9.6–10.2 μM. Furthermore, they showed modest cytotoxic activities against HL‐60, Hep‐G2, and SK‐OV‐3 cell lines with IC 50 values in the range of 17.2–42.6 μM [21] …”

Chemical Components and Pharmacological Activities of Terpene Natural Products from the Genus Paeonia

“…In 2012, four noroleanane triterpenes 103–106 were obtained from P. emodi [55]. In addition, in 2016, two new nortriterpenoids, paeonenoides D (107) and paeonenoides E (108), were obtained from P. lactiflora [56]. Their structures, 78–108 are shown below, and their names are collected in Figure 4.…”

“…Paeoniflorin (15) inhibiting inflammation and inducible nitric oxide synthase signaling pathways, and ameliorates acute myocardial infarction of rat [3]. Compounds 107, 108 were showed inhibitory effects against nitric oxide production in LPS-induced RAW246.7 macrophages [56].…”

“…A few of the compounds showed significant cytotoxicity against a panel of human cancer cell lines. Compound 95 against MCF-7, HT-29, M-14 [57]; Compounds 104–106 against A549, HCT116, HL-60, ZR-75-30; Compounds 104–106 against HL-60, HCT116 and ZR-75-30 [58]; Compounds 107, 108 against Hep-G2, SK-OV-3, HL-60 [56].…”