Design, Synthesis, and Evaluation of α‐(Hydroxymethyl)cycloalkanols

Abstract

α‐(Hydroxymethyl)cycloalkanols are pervasive structural scaffolds found in natural products and synthetic intermediates with varied biochemical and physicochemical properties. These profiles have driven numerous research groups to the synthesis of such motifs using innovative methodologies. The presence of vicinal diols attached to a cycloalkane makes from these motifs excellent synthetic intermediates for the synthesis of diverse ring systems. This investigation takes an overview of the literature for the occurrence and synthesis of α‐(hydroxymethyl)cycloalkanol derivatives, concentrating on advances in the last two decades.

Scalable Syntheses and Biological Evaluation of Africane‐Type Sesquiterpenoids

“…Fraga, González-Coloma, and co-workers reported the insect anti-feedant activities of several africanes that were isolated from transformed root cultures of a plant and exhibited insect cell-selective cytotoxicity. [13,14] Over the more than forty years since africanol (1) was isolated, the potential bioactivity of africanes has been discussed in several reports, [15,16] however, structure-activity relationship (SAR) studies to identify the most crucial functional group or architecture for activity were rarely included.…”