Paediatric aspects of COVID-19: An update

Kammoun, Rim; Masmoudi, Kaouthar

doi:10.1016/j.resmer.2020.100765

Cited by 11 publications

(25 citation statements)

References 31 publications

(41 reference statements)

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“…It has been postulated that the presence of lesser ACE-2 receptors (leading to decreased viral entry into host cells) and a higher activity of the innate immune system because of more proportion of natural killer cell and lymphocytes (resulting in more viral lysis)[ 46 ] can be the reason behind less severe infection in children. [ 47 ]…”

Section: Discussionmentioning

confidence: 99%

Gender and genetic factors impacting COVID-19 severity

Mishra

Ranjan

Ravindra

2021

J Family Med Prim Care

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COVID-19 pandemic is a cause of global concern and is impacting lives and economy globally. Infection due to SARS-CoV-2 leads to varied clinical manifestations, which can vary from asymptomatic to severe acute respiratory syndrome and death. The clinical features are proposed to depend upon various host factors, namely, gender and genetic factors. The significantly high mortality among males has revealed the role of gender, androgens, age, genetics, and risk factors in determining the severity of COVID-19 among the population. The interplay of various host factors and their association with clinically severe infections is crucial for our understanding of COVID-19 pathogenesis. A PubMed and Google scholar search was made using keywords such as “COVID-19 + sex differences,” “COVID-19 + androgens,” “COVID-19 + ACE2 receptor,” and “COVID-19 + smoking alcoholism pregnancy.” The articles which highlight the association of gender and genetic factors to COVID-19 were selected and included in our study. It is mainly the primary care or family physicians who act as the first contact of COVID-19 patients. With the recent increase in SARS-CoV-2 infections in the Indian subcontinent and probability of upcoming surges, it has become imperative to understand its interaction with the various gender and genetic factors to devise effective triage and management protocols. Our review highlights the possible mechanisms by which these factors impact the severity of COVID-19. A better understanding of these factors will be of immense help to primary care physicians.

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Section: Discussionmentioning

confidence: 99%

Gender and genetic factors impacting COVID-19 severity

Mishra

Ranjan

Ravindra

2021

J Family Med Prim Care

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“…La mayoría de niños que se encuentran en esta etapa presenta alguna comorbilidad, y puede presentarse en el 0.4% del total de pacientes. (7,9,10) .…”

Section: Manifestaciones Clínicasunclassified

Manifestaciones pulmonares y radiológicas del Sars-Cov2 en pediatría

Madrid¹,

Madrid-Mejía

Luna

et al. 2021

Act Ped Hond

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Las infecciones respiratorias agudas son causa de alta morbi-mortalidad a nivel mundial. El Coronavirus descubierto en Wuhan, China en el 2019 es de interés mundial por las diferentes manifestaciones clínicas que pueden aparecer en niños. Nuestro objetivo principal es revisar las manifestaciones del COVID-19 en el aparato respiratorio y los hallazgos a nivel radiológicos en pediatría. Se estiman que solo el 5,7% de los niños han sido hospitalizados, siendo los niños con comorbilidades y menores de 1 año los que suponen un riesgo mayor para enfermedad grave. A nivel global la mediana de edad de presentación de los casos es alrededor de 7 años, detectándose más casos a mayor edad, pero siendo la gravedad inversamente proporcional a la edad. La forma asintomática o leve son las presentaciones más comunes reportadas en niños, siendo de hasta en el 90% de los niños infectados. Los estudios de laboratorio pueden ser normales o presentar leucocitos alterados en un 69,2% y a nivel radiológico se ha observado en niños que en un 69% presentan opacidades bilaterales en vidrio despulido. En este momento, cualquier infección respiratoria aguda hay que descartar COVID-19, para poder evitar complicaciones en el paciente.

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Section: Introductionmentioning

confidence: 99%

“…While most severe cases have been reported in adults, the paediatric population appears to present with predominantly mild symptoms and disease course, except in children who have comorbid disease. 1 Typical symptoms in children include fever, cough, fatigue, dyspnoea, anorexia, diarrhoea and myalgia. 1 Myositis with rhabdomyolysis has been described in adult case reports, as well as in one adolescent.…”

Section: Introductionmentioning

confidence: 99%

“…1 Typical symptoms in children include fever, cough, fatigue, dyspnoea, anorexia, diarrhoea and myalgia. 1 Myositis with rhabdomyolysis has been described in adult case reports, as well as in one adolescent. 2 3 To our knowledge, this is the first such case in a child younger than 16 years and the first to be described in the context of multisystem inflammatory syndrome in children (MIS-C).…”

Section: Introductionmentioning

confidence: 99%

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